OBJECTIVE To evaluate the clinical response, adverse effects, and outcomes associated with palliative radiation therapy (PRT) in dogs with various solid tumor types at various body locations.
DESIGN Retrospective case series.
ANIMALS 103 dogs with solid tumors.
PROCEDURES Medical records for dogs with solid tumors treated with PRT between July 2007 and January 2011 at a veterinary teaching hospital were reviewed. Data collected included signalment, tumor type and location, initial staging results, PRT protocol, other tumor-specific treatments, patient and tumor response, outcome, and acute and chronic adverse effects. Median progression-free survival time, median survival time (MST), and other descriptive statistics were calculated.
RESULTS Types of tumors treated included carcinoma, sarcoma, melanoma, primary bone tumor, mast cell tumor, and ameloblastoma. For all dogs, the overall tumor and clinical response rates to PRT were 75% and 77%, respectively, and the MST was 134 days, but those responses varied substantially among tumor types. Dogs that developed a positive clinical response or maintained stable disease after PRT had a significantly longer MST than did dogs with progressive disease. Tumor location was not significantly associated with median progression-free survival time or MST. Most dogs tolerated the PRT well. Acute and chronic adverse effects were observed in 57 and 8 dogs, respectively, but were generally self-limiting.
CONCLUSIONS AND CLINICAL RELEVANCE Results indicated that dogs with various types of solid tumors that received PRT had objective beneficial responses and an improvement in quality of life that was positively associated with survival time.
Objective—To describe complications associated with use of a subcutaneous vascular access port (SVAP) in cats and dogs treated with fractionated radiotherapy and to determine predisposing factors for developing these complications.
Design—Retrospective case series.
Animals—46 cats and 126 dogs.
Procedures—The medical records of cats and dogs undergoing radiation therapy that received placement of an SVAP between March 1996 and August 2007 were reviewed. Data were recorded and analyzed to determine factors for development of complications associated with the use of an SVAP during treatment with fractionated radiotherapy.
Results—18 and 36 major and minor complications were identified, respectively. Sex and the lack of administration of propofol during anesthesia induction were significantly associated with development of major complications. Female cats and dogs were 5.00 times as likely as male cats and dogs to develop major complications associated with SVAP usage. Animals in which propofol was not administered were 19.15 times as likely as animals administered propofol to develop major complications. Placement of SVAP catheters in a femoral vein was 17.20 times as likely as placement in the jugular vein to result in minor complications.
Conclusions and Clinical Relevance—Factors associated with the development of complications included sex, propofol administration, and vein in which an SVAP catheter was inserted. The use of an SVAP may be a useful alternative to repeated catheterizations in cats and dogs.