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Signalment: An 8-year-old female mixed-breed pony that had been shown successfully as a hunter pony.

History: The pony was referred for evaluation because of a sudden onset of head tilt and circling. One day prior to the initial evaluation, the pony's head became tilted to the left with the neck turned to the right; the pony was reluctant to move to the left, but remained alert and responsive. Flunixin meglumine (1.1 mg/kg [0.5 mg/lb], IV, once) was administered with no improvement.

Physical examination: Findings of a physical examination were unremarkable.

Neurologic examination

What is the problem? Where

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in Journal of the American Veterinary Medical Association
History

A 20-year-old 582-kg warmblood mare was referred because of a 3-month history of pollakiuria and suspected sabulous cystitis, which is an accumulation of calcium carbonate sludge in the bladder leading to inflammation. Three weeks prior, the referring veterinarian performed a urinary workup, during which transrectal palpation revealed an enlarged bladder. A urinary catheter was passed, the bladder was drained, and a large amount of debris was noticed. Urinalysis and systemic bloodwork revealed no clinically remarkable abnormalities. No change in pollakiuria followed, and 1 week later, a urolith (approx 1 × 1 × 2 cm) covered with a blood clot

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in Journal of the American Veterinary Medical Association
History

A 6-year-old 500-kg (1,100-lb) multiparous Thoroughbred broodmare was referred to our veterinary hospital 3 days after parturition because of signs of colic; the mare was accompanied by its 3-day-old foal. The farm manager reported that parturition had been uncomplicated and that the mare had appeared to be comfortable until the day of referral; the referring veterinarian reported that the fetal membranes appeared to have been expelled in their entirety after parturition.

At the time of admission, results of physical examination were unremarkable, except for pale pink mucous membranes. Results for a CBC and venous blood gas analysis were within

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in Journal of the American Veterinary Medical Association

Abstract

CASE DESCRIPTION

A 17-year-old Friesian gelding was examined at a referral hospital because of a 1-month history of mild exercise intolerance and marked lymphocytosis.

CLINICAL FINDINGS

Physical examination revealed no peripheral lymphadenopathy or other abnormalities. Results of an abdominal palpation examination per rectum and thoracic and abdominal ultrasonographic examinations were unremarkable. B-cell chronic lymphocytic leukemia (CLL) was diagnosed on the basis of severe lymphocytosis and positive expression of the B-cell marker CD20 by lymphocytes in the bone marrow and peripheral blood.

TREATMENT AND OUTCOME

Treatment with prednisolone (2 mg/kg [0.9 mg/lb], PO, every other day) and chlorambucil (20 mg/m2, PO, every 3 weeks for 2 doses, then every 2 weeks) was initially associated with improvement in clinical signs and a decrease in the lymphocyte count. However, 3 weeks after administration of the first dose of chlorambucil, the lymphocyte count began to increase. One week later, the horse developed episodes of recurrent fever and the lymphocyte count continued to increase. Despite continued administration of the prednisolone-chlorambucil protocol, the horse's clinical condition deteriorated rapidly, and it was euthanized 6 weeks after initial examination at the referral hospital because of a poor prognosis. A necropsy was not performed.

CLINICAL RELEVANCE

B-cell CLL has been infrequently described in horses. This report was the first to describe the use of chemotherapy, albeit unsuccessful, for the treatment of B-cell CLL in a horse. This information should be useful for guiding expectations for prognosis and management of other horses affected with the disease.

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in Journal of the American Veterinary Medical Association