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  • Author or Editor: Kristin M. Patton x
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History

Ten days after calving, a 2-year-old registered Jersey cow was treated for endometritis with ceftiofur crystalline-free acid a injected SC at the base of the left ear. A month later, a small swelling was present at the injection site. The swelling continued to grow over the next several weeks. A presumptive diagnosis of an abscess or granuloma was made, and the mass was lanced and drained. Two months after initial treatment, a second small mass near the base of the left horn and a third mass in the center of the forehead were observed. The masses did not

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in Journal of the American Veterinary Medical Association

Abstract

Objective—To evaluate the local and systemic effects of IM implantation of lead shot alternatives in rats.

Animals—22 laboratory rats.

Procedures—Sterile IM implantation of shot metals was performed, with euthanasia and necropsy at 2, 8, 16, and 26 weeks after implantation. Skeletal muscle specimens were examined histologically and kidney specimens were tested for heavy metals. In vivo and in vitro evaluation of corrosion of metals was performed.

Results—Corrosion of susceptible metals was greatest at 2 weeks in vivo and in vitro. Inflammation associated with all pellet types was greatest 2 weeks after implantation. Nickel-plated steel incited significantly greater inflammation at 2 weeks, compared with bismuth alloy. Kidney iron concentration was significantly greater at 26 weeks, compared with other test periods. Local tissue deposition of iron was verified by use of Prussian blue staining for all iron-containing metals. Concentration of arsenic in kidneys was significantly greater at 8, 16, and 26 weeks after implantation, compared with 2 weeks.

Clinical Relevance and Impact for Human Medicine—Humans or dogs wounded with nickel-plated steel may require more aggressive initial monitoring than those wounded with other shot types. Monitoring of systemic arsenic concentrations may be indicated in patients wounded with shotgun pellets.

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in American Journal of Veterinary Research