Objective—To identify dietary and environmental risk
factors for hyperthyroidism in cats.
Animals—100 cats with hyperthyroidism and 163
Procedure—Medical records were examined, and
owners completed a mailed questionnaire. Data collected
included information regarding demographic
variables, environmental exposures, and diet, including
preferred flavors of canned cat food.
Results—Case cats were significantly less likely to
have been born recently than control cats. Housing;
exposure to fertilizers, herbicides, or plant pesticides;
regular use of flea products; and presence of a smoker
in the home were not significantly associated with
an increased risk of disease, but cats that preferred
fish or liver and giblets flavors of canned cat food had
an increased risk.
Conclusions and Clinical Relevance—Results suggest
that cats that prefer to eat certain flavors of
canned cat food may have a significantly increased
risk of hyperthyroidism. (J Am Vet Med Assoc 2000;
Objective—To quantify peripheral blood neutrophil apoptosis in equine patients with acute abdominal disease (ie, colic) caused by strangulating or nonstrangulating intestinal lesions and compare these values with values for horses undergoing elective arthroscopic surgery.
Animals—20 client-owned adult horses.
Procedures—Peripheral blood was collected from horses immediately prior to and 24 hours after surgery for treatment of colic (n = 10) or elective arthroscopic surgery (10), and neutrophils were counted. Following isolation by means of a bilayer colloidal silica particle gradient and culture for 24 hours, the proportion of neutrophils in apoptosis was detected by flow cytometric evaluation of cells stained with annexin V and 7-aminoactinomycin D. Values were compared between the colic and arthroscopy groups; among horses with colic, values were further compared between horses with and without strangulating intestinal lesions.
Results—Percentage recovery of neutrophils was significantly smaller in preoperative samples (median, 32.5%) and in all samples combined (35.5%) for the colic group, compared with the arthroscopy group (median, 66.5% and 58.0%, respectively). No significant differences in the percentages of apoptotic neutrophils were detected between these groups. Among horses with colic, those with strangulating intestinal lesions had a significantly lower proportion of circulating apoptotic neutrophils in postoperative samples (median, 18.0%) than did those with nonstrangulating lesions (66.3%).
Conclusions and Clinical Relevance—The smaller proportion of apoptotic neutrophils in horses with intestinal strangulation suggested that the inflammatory response could be greater or prolonged, compared with that of horses with nonstrangulating intestinal lesions. Further investigations are needed to better understand the relationship between neutrophil apoptosis and inflammation during intestinal injury.