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Abstract

Objective—To establish a dosing regimen for potassium bromide and evaluate use of bromide to treat spontaneous seizures in cats.

Design—Prospective and retrospective studies.

Animals—7 healthy adult male cats and records of 17 cats with seizures.

Procedure—Seven healthy cats were administered potassium bromide (15 mg/kg [6.8 mg/lb], PO, q 12 h) until steady-state concentrations were reached. Serum samples for pharmacokinetic analysis were obtained weekly until bromide concentrations were not detectable. Clinical data were obtained from records of 17 treated cats.

Results—In the prospective study, maximum serum bromide concentration was 1.1 ± 0.2 mg/mL at 8 weeks. Mean disappearance half-life was 1.6 ± 0.2 weeks. Steady state was achieved at a mean of 5.3 ± 1.1 weeks. No adverse effects were detected and bromide was well tolerated. In the retrospective study, administration of bromide (n = 4) or bromide and phenobarbital (3) was associated with eradication of seizures in 7 of 15 cats (serum bromide concentration range, 1.0 to 1.6 mg/mL); however, bromide administration was associated with adverse effects in 8 of 16 cats. Coughing developed in 6 of these cats, leading to euthanasia in 1 cat and discontinuation of bromide administration in 2 cats.

Conclusions and Clinical Relevance—Therapeutic concentrations of bromide are attained within 2 weeks in cats that receive 30 mg/kg/d (13.6 mg/lb/d) orally. Although somewhat effective in seizure control, the incidence of adverse effects may not warrant routine use of bromide for control of seizures in cats. (J Am Vet Med Assoc 2002;221:1131–1135)

Full access
in Journal of the American Veterinary Medical Association

Summary

Brain stem auditory evoked potential (baep) testing with air-conducted click stimuli can be used to diagnose sensorineural deafness in dogs if conductive deafness can be ruled out. Detection of conductive deafness can be performed by recording baep elicited by a vibratory stimulus transducer placed against the skull. Air- and bone-conducted baep were compared in dogs, varying bone stimulator placement, click polarity, and stimulus intensity. Optimal bone stimulator placement was determined to be over the mastoid process, followed by the mandible and the zygomatic arch. Condensation polarity clicks gave responses preferable to those elicited by rarefaction or alternating polarity. Bone-conducted baep peak latencies were significantly longer than air-conducted latencies after correction of the latencies for the air conduction time accompanying air-conducted stimuli. Significant differences between stimulus modalities were not seen for baep peak amplitudes or interpeak latencies. Latency-intensity and amplitude-intensity regressions had similar effects for both modalities: latencies decreased and amplitudes increased as stimulus intensity increased.

Free access
in American Journal of Veterinary Research