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  • Author or Editor: Kelly L. Gellasch x
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Objective—To evaluate whether body size and anatomic site influence the quantity of bone microdamage in dogs without osteosarcoma (OS).

Sample Population—Pairs of radii were collected from 10 small dogs (< 15 kg) and 10 large dogs (> 25 kg).

Procedure—Specimens were stained in basic fuchsin for bone microdamage. Transverse sections were cut from each proximal and distal radial metaphysis at 15 and 85% of bone length. The following variables were determined for each region: mean microcrack length (CrLe, µm), microcrack density (CrDn, microcracks/mm2), microcrack surface density (CrSDn, µm/mm2), and estimated activation frequency (Acf, microcracks/mm2/y).

Results—Metaphyseal region did not significantly influence CrDn, CrLe, and CrSDn. The CrDn and CrSDn were influenced by body size, with microdamage being increased in large dogs, compared with small dogs. However, mean CrLe was not significantly influenced by body size. Acf significantly decreased with age and was significantly decreased in large dogs and in the distal radial metaphysis, compared with small dogs and the proximal radial metaphysis, respectively.

Conclusion and Clinical Relevance—Our data did not reveal an increase in microdamage or remodeling at the OS predilection site (ie, the distal metaphysis of the radius), suggesting that induction of microdamage and an associated increase in bone remodeling are unlikely to be an important risk factor for induction of OS. (Am J Vet Res 2002;63:896–899)

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in American Journal of Veterinary Research
in Journal of the American Veterinary Medical Association
in Journal of the American Veterinary Medical Association


Objective—To compare postoperative discomfort assessed by subjective pain score and plasma cortisol concentrations in cats undergoing onychectomy that received analgesia by use of transdermal fentanyl (TDF) patches or an IM injection of butorphanol.

Design—Randomized prospective clinical trial.

Animals—22 client-owned cats weighing 2.2 to 5 kg (4.84 to 11 lb) undergoing onychectomy.

Procedure—Researchers were blinded to which cats received a TDF patch (25 µg/h) 18 to 24 hours prior to surgery or an IM injection of butorphanol (0.2 mg/kg [0.09 mg/lb]) at the time of sedation, immediately following extubation, and at 4-hour intervals thereafter for 12 hours. Clinical variables, plasma cortisol concentration, and pain scores were evaluated and recorded 24 hours prior to surgery, at extubation, and 2, 4, 8, 12, 24, 36, and 48 hours after surgery.

Results—The TDF group had a lower pain score than the butorphanol group only at 8 hours after surgery. Both groups had significantly lower mean plasma cortisol concentrations 0, 24, 36, and 48 hours after surgery, compared with mean plasma cortisol concentrations prior to surgery. No significant differences in appetite or response to handling the feet were observed between the 2 groups.

Conclusions and Clinical Relevance—Our data did not reveal a difference in pain relief between administration of TDF and butorphanol. Plasma cortisol concentrations were not different between groups. Fentanyl appeared to provide equivalent analgesia to butorphanol in cats undergoing onychectomy. The primary advantage of using a TDF patch is that repeated injections are not required. (J Am Vet Med Assoc 2002;220:1020–1024)

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in Journal of the American Veterinary Medical Association