Objective—To evaluate the effects of deracoxib and aspirin on serum concentrations of thyroxine (T4), 3,5,3′-triiodothyronine (T3), free thyroxine (fT4), and thyroid-stimulating hormone (TSH) in healthy dogs.
Procedure—Dogs were allocated to 1 of 3 groups of 8 dogs each. Dogs received the vehicle used for deracoxib tablets (PO, q 8 h; placebo), aspirin (23 to 25 mg/kg, PO, q 8 h), or deracoxib (1.25 to 1.8 mg/kg, PO, q 24 h) and placebo (PO, q 8 h) for 28 days. Measurement of serum concentrations of T4, T3, fT4, and TSH were performed 7 days before treatment (day −7), on days 14 and 28 of treatment, and 14 days after treatment was discontinued. Plasma total protein, albumin, and globulin concentrations were measured on days −7 and 28.
Results—Mean serum T4, fT4, and T3 concentrations decreased significantly from baseline on days 14 and 28 of treatment in dogs receiving aspirin, compared with those receiving placebo. Mean plasma total protein, albumin, and globulin concentrations on day 28 decreased significantly in dogs receiving aspirin, compared with those receiving placebo. Fourteen days after administration of aspirin was stopped, differences in hormone concentrations were no longer significant. Differences in serum TSH or the free fraction of T4 were not detected at any time. No significant difference in any of the analytes was detected at any time in dogs treated with deracoxib.
Conclusions and Clinical Relevance—Aspirin had substantial suppressive effects on thyroid hormone concentrations in dogs. Treatment with high dosages of aspirin, but not deracoxib, should be discontinued prior to evaluation of thyroid function.
Objective—To determine the prevalence of systemic
hypertension in cats with diabetes mellitus and establish
ranges for echocardiographic variables in diabetic
Animals—14 cats with diabetes mellitus and 19
healthy control cats.
Procedure—Systolic blood pressure was measured
indirectly with a noninvasive Doppler technique.
Ophthalmic and echocardiographic examinations
were performed, and urine protein concentration was
measured. Cats were considered to have hypertension
if they had systolic blood pressure > 180 mm Hg
and at least 1 other clinical abnormality typically associated
with hypertension (eg, hypertensive retinopathy,
left ventricular hypertrophy, or proteinuria).
Results—None of the diabetic or control cats had
systolic blood pressure > 180 mm Hg. One diabetic
cat had left ventricular hypertrophy, but systolic blood
pressure was 174 mm Hg. None of the cats had evidence
of hypertensive retinopathy or proteinuria.
Mean values for echocardiographic variables for the
diabetic cats were not significantly different from published
values for healthy cats.
Conclusions and Clinical Relevance—Results suggest
that hypertension does not occur or occurs in
only a small percentage of cats with diabetes mellitus.
(J Am Vet Med Assoc 2003;223:198–201)