Objective—To determine the efficacy of triamcinolone
acetonide topical solution (TTS) in dogs for use in
reduction of clinical signs of pruritic inflammatory skin
diseases of a known or suspected allergic basis and
to evaluate adverse effects associated with TTS
Animals—103 pruritic adult dogs with known or suspected
allergic skin disease.
Procedure—Dogs were treated for 4 weeks with TTS
or with vehicle solution (control dogs) in a multiplecenter
study. Clinical signs were scored by owners
and by examining veterinarians before and after treatment.
Blood samples obtained before and after treatment
were subjected to routine hematologic and
serum biochemical analyses.
Results—Treatment success, as defined by an
improvement of at least 2 of 6 grades in overall
clinical score, was evident in 35 of 52 (67%) TTStreated
dogs (mean improvement, 1.98) and 12 of
51 (24%) control dogs (mean improvement, 0.29).
For several criteria, TTS was significantly more
effective than vehicle in reducing clinical signs.
Minor alterations in hematologic determinations in
TTS-treated dogs were limited to slightly lower
total leukocyte, lymphocyte, and eosinophil counts
after treatment. Minor adverse effects were reported
by owners in 6 of 52 (12%) TTS-treated and 9 of
51 (18%) control dogs.
Conclusions and Clinical Relevance—Triamcinolone
used as a spray solution at a concentration approximately
one-sixth the concentration of triamcinolone
topical preparations currently available for veterinary
use is effective for short-term alleviation of allergic
pruritus in dogs. Adverse effects are few and mild
and, thus, do not preclude prolonged treatment with
the solution. (Am J Vet Res 2002;63:408–413)
Objectives—To determine the effects of racing and
training on serum thyroxine (T4), triiodothyronine (T3),
and thyroid stimulating hormone (TSH) concentrations
Animals—9 adult racing Greyhounds.
Procedure—Serum thyroid hormone concentrations
were measured before and 5 minutes after a race in
dogs trained to race 500m twice weekly for 6 months.
Resting concentrations were measured again when
these dogs had been neutered and had not raced for
3 months. Postrace concentrations were adjusted relative
to albumin concentration to allow for effects of
hemoconcentration. Thyroid hormone concentrations
were then compared with those of clinically normal
dogs of non-Greyhound breeds.
Results—When adjusted for hemoconcentration,
total T4 concentrations increased significantly after
racing and TSH concentrations decreased; however,
there was no evidence of a change in free T4 or total
or free T3 concentrations. Resting total T4 concentrations
increased significantly when dogs had been
neutered and were not in training. There was no evidence
that training and neutering affected resting
TSH, total or free T3, or free T4 concentrations.
Resting concentrations of T3, TSH, and autoantibodies
against T4, T3, and thyroglobulin were similar to those
found in other breeds; however, resting free and total
T4 concentrations were lower than those found in
Conclusions and Clinical Relevance—Except for
total T4, thyroid hormone concentrations in
Greyhounds are affected little by sprint racing and
training. Greyhounds with low resting total and free T4
concentrations may not be hypothyroid. (Am J Vet