OBJECTIVE To identify risk factors for anesthetic-related death in pet dogs and cats.
DESIGN Matched case-control study.
ANIMALS 237 dogs and 181 cats.
PROCEDURES Electronic medical records from 822 hospitals were examined to identify dogs and cats that underwent general anesthesia (including sedation) or sedation alone and had death attributable to the anesthetic episode ≤ 7 days later (case animals; 115 dogs and 89 cats) or survived > 7 days afterward (control animals [matched by species and hospital]; 122 dogs and 92 cats). Information on patient characteristics and data related to the anesthesia session were extracted. Conditional multivariable logistic regression was performed to identify factors associated with anesthetic-related death for each species.
RESULTS The anesthetic-related death rate was higher for cats (11/10,000 anesthetic episodes [0.11%]) than for dogs (5/10,000 anesthetic episodes [0.05%]). Increasing age was associated with increased odds of death for both species, as was undergoing nonelective (vs elective) procedures. Odds of death for dogs were significantly greater when preanesthetic physical examination results were not recorded (vs recorded) or when preanesthetic Hct was outside (vs within) the reference range. Odds of death for cats were greater when intra-anesthesia records for oxygen saturation as measured by pulse oximetry were absent. Underweight dogs had almost 15 times the odds of death as nonunderweight dogs; for cats, odds of death increased with increasing body weight (but not with overweight body condition).
CONCLUSIONS AND CLINICAL RELEVANCE Several factors were associated with anesthetic-related death in cats and dogs. This information may be useful for development of strategies to reduce anesthetic-related risks when possible and for education of pet owners about anesthetic risks.
Objective—To determine incidence rates and potential
risk factors for vaccine-associated adverse events
(VAAEs) diagnosed within 3 days of administration in
Design—Retrospective cohort study.
Animals—1,226,159 dogs vaccinated at 360 veterinary
Procedure—Electronic records from January 1, 2002,
through December 31, 2003, were searched for possible
VAAEs (nonspecific vaccine reaction, allergic
reaction, urticaria, or anaphylaxis) diagnosed within 3
days of vaccine administration. Information included
age, weight, sex, neuter status, and breed. Specific
clinical signs and treatments were reviewed in a random
sample of 400 affected dogs. The association
between potential risk factors and a VAAE was estimated
by use of multivariate logistic regression.
Results—4,678 adverse events (38.2/10,000 dogs
vaccinated) were associated with administration of
3,439,576 doses of vaccine to 1,226,159 dogs. The
VAAE rate decreased significantly as body weight
increased. Risk was 27% to 38% greater for neutered
versus sexually intact dogs and 35% to 64% greater
for dogs approximately 1 to 3 years old versus 2 to 9
months old. The risk of a VAAE significantly increased
as the number of vaccine doses administered per
office visit increased; each additional vaccine significantly
increased risk of an adverse event by 27% in
dogs ≤ 10 kg (22 lb) and 12% in dogs > 10 kg.
Conclusions and Clinical Relevance—Young adult
small-breed neutered dogs that received multiple vaccines
per office visit were at greatest risk of a VAAE
within 72 hours after vaccination. These factors
should be considered in risk assessment and risk
communication with clients regarding vaccination.
(J Am Vet Med Assoc 2005;227:1102–1108)