Search Results

You are looking at 1 - 4 of 4 items for

  • Author or Editor: Joseph M. Cummins x
  • Refine by Access: All Content x
Clear All Modify Search
in American Journal of Veterinary Research

SUMMARY

Cytologic examination of bronchoalveolar lavage fluid (balf), including phenotypic analysis of lymphocytes, was performed on 32 Standardbreds with poor race performance and endoscopic examination findings characteristic of inflammatory airway disease (iad). Nucleated cell counts in balf from iad-affected horses were higher than those in control horses; the cytologic profile of balf in affected horses included mixed inflammation, characterized by mild neutrophilia, lymphocytosis, and monocytosis. Eosinophil and mast cell counts were not higher in the iad-affected group, compared with those in the control group; however, 4 iad-affected horses had marked eosinophilia (24.7 ± 4.8% SEM) in balf. Phenotypic analysis of lymphocytes in balf obtained from IAD-affected horses revealed a low proportion of CD4-positive cells and B cells, compared with those in the control group; these findings may have been representative of a greater proportion of non-B, non-T cells (null cells) in horses with iad. The cytologic profile of balf obtained from horses with iad differed from that in horses affected with chronic obstructive pulmonary disease, suggesting that the pathogenesis of inflammation in horses with iad may differ from that of chronic obstructive pulmonary disease.

Free access
in American Journal of Veterinary Research

SUMMARY

The immunotherapeutic effect of low-dose human alpha interferon on viral shedding and clinical disease was evaluated in horses inoculated with equine herpesvirus- 1 (ehv-1). Eighteen clinically healthy weanling horses, 5 to 7 months old, were allotted to 3 equal groups. Two groups were treated orally with human α-2a interferon (0.22 or 2.2 U/kg of body weight), on days 2 and 1 before inoculation with ehv-1, the day of inoculation, and again on postinoculation day 1. The horses of the remaining group were given a placebo orally on the same days. The horses were monitored daily for changes in body temperature and for clinical signs of respiratory tract disease. Blood and nasal swab specimens were collected daily for virus isolation. Blood was also collected at intervals throughout the monitoring period for evaluation of cbc, serum IgG and IgM concentrations, and antibody titers to ehv-1. Febrile responses, nasal discharge, viral shedding, changes in cbc, and an increase in antibody titers to ehv-1 were noticed in all horses after inoculation. There was no significant difference (P > 0.05) in mean values of the factors measured between treatment and control groups.

Free access
in American Journal of Veterinary Research