Objective—To evaluate the effects of a pico-tesla
electromagnetic field (PTEF) on healing of sutured
and open skin wounds and clinicopathologic variables
Animals—64 male Fischer-344 rats.
Procedure—An incision made in the dorsal aspect of
the neck was sutured (n = 32) or left open to heal (32).
In each group, 16 rats were not PTEF-treated (controls).
Wound treatment consisted of exposure to a
PTEF once daily. Rats in each group were euthanatized
at days 2, 4, 7, and 14. Wounds were evaluated
via tensiometry (sutured wounds), digital planimetry
(open wounds), laser Doppler perfusion imaging, bacteriologic
culture, and histologic examination. Blood
samples were collected from all rats for analysis.
Results—At day 14, sutured wounds in PTEF-treated
rats were stronger (ultimate stress) and tougher
(strain energy) than were sutured wounds in control
rats. Open wounds in PTEF-treated rats contracted
more quickly at days 2 and 4 than did those in control
rats. Compared with control wounds, histologic
changes (indicative of improved healing) in sutured
and open wounds in PTEF-treated rats were detected
as early as day 4. Laser Doppler perfusion measurements,
results of CBCs, serum biochemical analyses,
and bacteriologic cultures were not different between
Conclusions and Clinical Relevance—Exposure to
the PTEF caused no adverse effects on clinicopathologic,
histologic, or bacteriologic variables tested in
this study. It appears that PTEF is a safe form of adjuvant
treatment for wounds and improves strength of
sutured wounds and speeds contraction of open
wounds. (Am J Vet Res 2003;64:845–854)