Objective—To evaluate the efficacy of ceftiofur
hydrochloride sterile suspension administered parenterally
for treatment of acute postpartum metritis
(APM) in dairy cows.
Design—Multilocation, randomized block, field trial.
Animals—406 cows in the first 14 days postpartum.
Procedure—Cows with rectal temperatures ≥
39.5°C (103.1°F) without clinical signs of respiratory
or gastrointestinal tract disease and with a fetid
vaginal discharge were allocated randomly in
blocks of 3 to 3 treatment groups: sterile saline
(0.9% NaCl) solution administered at a dosage of 2
mL/45.4 kg (2 mL/100 lb), SC or IM, once daily for
5 days (control); or ceftiofur hydrochloride administered
at a dosage of 1.1 or 2.2 mg of ceftiofur
equivalents (CE)/kg (0.5 or 1 mg/lb, respectively),
SC or IM, once daily for 5 days. Cows were evaluated
on days 6, 10, and 14, and clinical cure or failure
to cure was determined. Clinical cure was
defined as no additional antimicrobial treatment
administered, rectal temperature < 39.5°C, and
absence of a fetid vaginal discharge.
Results—On day 14, clinical cure rates were 77%,
65%, and 62% for the 2.2 mg of CE/kg, 1.1 mg of
CE/kg, and control groups, respectively. No significant
differences were detected in clinical cure
rates between control and treatment groups on day
10 or 6.
Conclusions and Clinical Relevance—Ceftiofur
hydrochloride administered at a dosage of 2.2 mg of
CE/kg, SC or IM, once daily for 5 days was efficacious for
treatment of APM in dairy cows. (J Am Vet Med Assoc