Objective—To assess antiulcerogenic properties of 3
Animals—8 healthy adult mares.
Procedure—A protocol to induce gastric ulcers was
used and included 240 mL of water plus corn oil,
refined rice bran oil, or crude rice bran oil administered
each day for 6 weeks according to a 4 × 4 Latin
square randomized crossover design with 5-week
washout intervals. A 7-day alternating feed deprivation
period was included between weeks 5 and 6.
Omeprazole was administered daily for the last 14
days of each washout interval. Endoscopic examinations
of the stomach were performed at 0, 5, and 6
weeks, and the number (0 to 4 scale) and severity (0
to 5 scale) of ulcers were scored. Gastric fluid was
collected at 0 and 5 weeks.
Results—Median body weight significantly increased
by 29 kg (range, 10 to 50 kg). Mean ± SE gastric fluid
pH significantly decreased from 4.9 ± 0.4 to 3.1 ± 0.3
over 5 weeks, and total volatile fatty acid concentration
significantly decreased over time. Mean ± SE
severity of nonglandular ulcers significantly increased
from 0.4 ± 0.1 to 1.2 ± 0.2 over 5 weeks.
Nonglandular ulcers significantly increased in number
(mean ± SE, 1.3 ± 0.2 to 3.0 ± 0.2) and severity (mean
± SE, 1.2 ± 0.2 to 2.6 ± 0.2) during the 7-day alternating
feed deprivation period. No effects of treatment
Conclusions and Clinical Relevance—In this model
dietary oils did not prevent gastric ulcers from forming
in the nonglandular portion of the stomach of horses.
(Am J Vet Res 2005;66:2006–2011)
Objective—To determine survival time for dogs with splenic hemangiosarcoma treated with splenectomy alone, identify potential prognostic factors, and evaluate the efficacy of adjuvant chemotherapy.
Design—Retrospective case series.
Procedures—Medical records were reviewed, long-term follow-up information was obtained, and survival data were analyzed statistically.
Results—154 dogs were treated with surgery alone, and 54 were treated with surgery and chemotherapy. Twenty-eight dogs received conventional chemotherapy, 13 received cyclophosphamide-based metronomic chemotherapy, and 13 received both conventional and metronomic chemotherapy. Median survival time of dogs treated with splenectomy alone was 1.6 months. Clinical stage was the only prognostic factor significantly associated with survival time. When the entire follow-up period was considered, there was no significant difference in survival time between dogs treated with surgery alone and dogs treated with surgery and chemotherapy. However, during the first 4 months of follow-up, after adjusting for the effects of clinical stage, survival time was significantly prolonged among dogs receiving any type of chemotherapy (hazard ratio, 0.6) and among dogs receiving both conventional and metronomic chemotherapy (hazard ratio, 0.4).
Conclusions and Clinical Relevance—Clinical stage was strongly associated with prognosis for dogs with splenic hemangiosarcoma. Chemotherapy was effective in prolonging survival time during the early portion of the follow-up period. Combinations of doxorubicin-based conventional protocols and cyclophosphamide-based metronomic protocols appeared to be more effective than either type of chemotherapy alone, but prolongations in survival time resulting from current protocols were modest.