OBJECTIVE To assess multiple central venous and arterial blood variables that alone or in conjunction with one another reflect global oxygenation status in healthy neonatal foals.
ANIMALS 11 healthy neonatal foals.
PROCEDURES Central venous and arterial blood samples were collected from healthy neonatal foals at 12, 24, 36, 48, 72, and 96 hours after birth. Variables measured from central venous and arterial blood samples included oxygen saturation of hemoglobin, partial pressure of oxygen, lactate concentration, partial pressure of carbon dioxide, and pH. Calculated variables included venous-to-arterial carbon dioxide gap, estimated oxygen extraction ratio, ratio of partial pressure of oxygen in arterial blood to the fraction of inspired oxygen, bicarbonate concentration, base excess, and blood oxygen content.
RESULTS Significant differences between arterial and central venous blood obtained from neonatal foals were detected for several variables, particularly partial pressure of oxygen, oxygen saturation of hemoglobin, and oxygen content. In addition, the partial pressure of carbon dioxide in central venous blood samples was significantly higher than the value for corresponding arterial blood samples. Several temporal differences were detected for other variables.
CONCLUSIONS AND CLINICAL RELEVANCE Results of this study provided information about several variables that reflect global oxygenation in healthy neonatal foals. Values for these variables in healthy foals can allow for comparison with values for critically ill foals in future studies. Comparison of these variables between healthy and ill foals may aid in treatment decisions and prognosis of clinical outcome for critically ill foals.
Objective—To evaluate the effects of 25% diet
restriction on life span of dogs and on markers of
Design—Paired feeding study.
Animals—48 Labrador Retrievers.
Procedures—Dogs were paired, and 1 dog in each
pair was fed 25% less food than its pair-mate from 8
weeks of age until death. Serum biochemical analyses
were performed, body condition was scored, and
body composition was measured annually until 12
years of age. Age at onset of chronic disease and
median (age when 50% of the dogs were deceased)
and maximum (age when 90% of the dogs were
deceased) life spans were evaluated.
Results—Compared with control dogs, food-restricted
dogs weighed less and had lower body fat content
and lower serum triglycerides, triiodothyronine,
insulin, and glucose concentrations. Median life span
was significantly longer for dogs in which food was
restricted. The onset of clinical signs of chronic disease
generally was delayed for food-restricted dogs.
Conclusions and Clinical Relevance—Results suggest
that 25% restriction in food intake increased
median life span and delayed the onset of signs of
chronic disease in these dogs. (J Am Vet Med Assoc