Objective—To assess gross and histologic tissue
responses of skin incisions closed by use of
absorbable subcuticular staples, cutaneous metal staples,
and polyglactin 910 suture in pigs.
Animals—8 purpose-bred disease-free pigs.
Procedure—Pigs were randomly allocated to 1 of 4
groups from which tissues were collected after
death on postoperative days (PODs) 7, 14, 21, or
42. In each pig, 4 incisions were made; 1 was
closed subcuticularly with 3-0 polyglactin 910
suture, 1 was closed with metal staples, and 2
were closed with absorbable subcuticular staples.
Incision sites were grossly evaluated every 3 days
after closure. At necropsy, incision sites and surrounding
tissues were examined histologically; a
histopathologic scoring system was used to quantitate
healing and tissue response directed against
the closure material.
Results—Postoperatively, the metal staples induced
a severe inflammatory response, compared with minimal
inflammation associated with the suture or
absorbable subcuticular staples. Histologic evaluation
of incisions on PODs 7, 14, and 21 revealed less
severe inflammation associated with absorbable subcuticular
staples than that associated with the other
Conclusions and Clinical Relevance—Results indicated
that absorbable subcuticular staples induced a
less severe inflammatory response in the early
stages of healing in pigs, compared with other commonly
used methods of wound closure. Use of
absorbable staples potentially combines the benefits
of subcuticular closure with the speed and precision
of staple placement. (Am J Vet Res