Objective—To evaluate survival time of dogs with
idiopathic Fanconi syndrome.
Animals—60 dogs with idiopathic Fanconi syndrome.
Procedure—Data were collected by means of questionnaires
distributed to owners and veterinarians of
dogs with idiopathic Fanconi syndrome and by examination
of medical records when accessible.
Questionnaires and records were reviewed for criteria
used in diagnosis, treatments administered, survival
time, and subjective owner perceptions regarding
their dogs' general condition.
Results—58 of the dogs were Basenjis. Fifty-seven
dogs (95%) were reportedly managed by use of a single
therapeutic regimen. Median survival time after
diagnosis of Fanconi syndrome was 5.25 years; median
estimated lifespan was calculated to be between
11.3 and 12.1 years. Owners of 28 of 29 (97%) dogs
still alive at the time of the study subjectively
assessed their dogs' general condition as good to
excellent. Seizures or other neurologic dysfunction
was reported for 11 dogs.
Conclusions and Clinical Relevance—Results suggest
that expected lifespan for dogs with idiopathic
Fanconi syndrome was not substantially reduced,
compared with expected lifespan for unaffected dogs,
and that affected dogs generally had a good to excellent
quality of life, as subjectively assessed by their
owners. What effect the treatment regimen had on
survival time or lifespan could not be determined,
given the small number of dogs managed with other
methods. The high percentage of dogs with neurologic
abnormalities was a concern, but whether this
was related to Fanconi syndrome or represented a
breed-related predisposition to neurologic disease
could not be determined. ( J Am Vet Med Assoc 2004;225:377–383)