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  • Author or Editor: Jean A. Nemzek x
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Abstract

OBJECTIVE To determine long-term outcome for rhesus macaques (Macaca mulatta) with endometriosis that underwent surgical treatment and identify factors potentially associated with long-term outcome.

DESIGN Retrospective case series.

ANIMALS 11 female rhesus macaques.

PROCEDURES Medical records of female rhesus macaques in which endometriosis was diagnosed between 2007 and 2011 and that underwent abdominal exploratory surgery were reviewed.

RESULTS In 5 macaques, the only clinical abnormality was a caudal abdominal mass identified during a routine physical examination, and in 6 macaques, overt clinical signs of endometriosis, including anorexia, dysmenorrhea, and lethargy during menses, were reported. Five macaques had histologically confirmed complete ovarian removal, and another 5 had incomplete ovarian removal (ovarian tissue was not examined histologically in 1 macaque). Nine animals survived at least 12 months after surgery, and 6 survived at least 60 months after surgery. Macaques that did not have overt clinical signs were significantly more likely to survive at least 60 months after surgery. However, extent of ovarian removal was not significantly associated with survival 12 or 60 months after surgery.

CONCLUSIONS AND CLINICAL RELEVANCE Results suggested that, in select situations, surgery (ovariectomy or ovariohysterectomy) may be curative in macaques with endometriosis and may result in long-term survival. Further, findings suggested that monitoring until clinical signs appear before performing surgery is not warranted in adult female macaques suspected to have endometriosis that only have a caudal abdominal mass and no other overt clinical signs.

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in Journal of the American Veterinary Medical Association
in Journal of the American Veterinary Medical Association
History

A 14.5-year-old sexually intact female rhesus macaque (Macaca mulatta) was evaluated as part of a routine semiannual physical examination. This macaque was part of a colony used for pharmacological studies and was currently enrolled in such a study.

The macaque was housed at a university facility accredited by the Association for the Assessment and Accreditation of Laboratory Animal Care International. It arrived at the facility in 2003, and its medical history and reproductive history prior to arrival at the facility were unknown. The macaque had a history of fluctuations in weight (6.7 to 8.0 kg [14.74 to

Restricted access
in Journal of the American Veterinary Medical Association