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  • Author or Editor: J. R. Duimstra x
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Changes in the common bile duct that contained adult Fasciola hepatica of sheep were evaluated by light (lm) and scanning electron microscopy (sem). Nine ewes were inoculated with F hepatica metacercariae and necropsied 18 weeks after inoculation. The proximal portion of the common bile duct (cbd) that contained adult flukes was recovered and examined by lm and sem. The cbd from 2 noninoculated ewes were used for control.

On gross examination, cbd were markedly large because of the adult flukes, which were free in the lumen of the ducts. Extensive hemorrhage was not found either in intrahepatic or in extrahepatic bile ducts of any sheep. Histologic examination revealed changes, such as villous hyperplasia and hypertrophy of the epithelium; cell infiltration, predominately with eosinophils or macrophages; and arterial intimal proliferation. By sem, the epithelial surface of the cbd appeared intact. Villous hyperplasia and hypertrophy of the epithelium observed by lm was clearly seen by sem. Epithelial damage, seen as small areas of denuded surface by lm and sem, was confined to a few areas of the mucosa. Lack of extensive hemorrhage and confined epithelial damage were evaluated relative to the mode of feeding of adult flukes.

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in American Journal of Veterinary Research