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  • Author or Editor: J. L. Cornick x
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Cardiopulmonary and behavioral effects of the following tranquilizer-opioid drug combinations were compared in conscious dogs: acepromazine (0.22 mg/kg of body weight, iv) and butorphanol (0.22 mg/kg, iv); acepromazine (0.22 mg/kg, im) and butorphanol (0.22 mg/kg, im); and acepromazine (0.22 mg/kg, iv) and oxymorphone (0.22 mg/kg, iv). Marked sedation and lateral recumbency that required minimal or no restraint was achieved with every drug combination. Analgesia was significantly better in dogs receiving oxymorphone than in dogs receiving butorphanol, as evaluated by response to toe pinch. There were no significant differences between the effects of the 3 drug combinations on heart rate, respiratory rate, arterial blood pressure, body temperature, and arterial pH, PCO2 , PO2 , and bicarbonate concentration. Heart rate, respiratory rate, and systolic arterial pressure decreased significantly over time with all drug combinations. Total recovery time (minutes from the initial injection to standing) was significantly longer in the dogs given acepromazine and oxymorphone.

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in Journal of the American Veterinary Medical Association


Cardiopulmonary effects of iv administered butorphanol tartrate (but) were assessed in 7 yearling steers medicated with atropine and anesthetized with guaifenesin, thiamylal sodium, and isoflurane in O2 for surgical placement of duodenal cannulae. Heart rate, respiratory rate, arterial blood pressures, pHa, Paco2 , Pao2 arterial [HCO3 -], esophageal temperature, and end-tidal isoflurane concentrations were measured before and after iv administration of but (10 mg).

Mean respiratory rate increased significantly (P < 0.05) only at 45 and 60 minutes after but administration. Mean respiratory rate was 26 ± 6.3 breaths/min before but administration and 46 ± 12.1 breaths/min 60 minutes after but administration. Arterial blood pressures were increased significantly (P < 0.05) at all times, except 5 minutes after but administration. The mean value for mean arterial pressure was 76 ± 9.6 mm of Hg before but injection and 117 ± 12.6 mm of Hg 60 minutes after but injection. Mean values for pHa and arterial [HCO3 -] were significantly (P < 0.05) higher at 60 minutes after but administration (baseline, pH = 7.25 ± 0.04 and [HCO3 -] = 29.9 ± 3.5 mEq/L; 60 minutes after but, pH = 7.28 ± 0.03 and [HCO3 -] = 33.0 ± 1.8 mEq/L). Although some statistically significant changes were recorded, iv administration of but to these steers did not have a marked effect on the cardiopulmonary variables measured.

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in American Journal of Veterinary Research