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  • Author or Editor: J. E. Sojka x
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SUMMARY

The effect of the somatostatin analogue, octreotide, on gastric fluid pH was investigated in 4 ponies. Gastric fluid pH was determined after sc administration of octreotide or physiologic saline solution (control). A baseline sample of fluid was obtained, the agent was given, and 8 additional samples were collected hourly. Administration of octreotide at all dosages tested (0.1, 0.5, 1.0, and 5.0 μg/kg of body weight) increased gastric pH to > 5.0. Baseline values were consistently < 2.7. Administration of octreotide at these same dosages induced gastric pH values > 4.0 for 2.4 ± 1.2, 4.8 ± 0.8, 5.7 ± 1.3, and 5.4 ± 2.6 (mean ± sd) continuous hours, respectively. Treatment at all dosages increased the pH of gastric fluid, compared with control values. The duration of the increase in pH was significantly (P < 0.05) different than that of the control treatment, even for the lowest dosage, 0.1 μg/kg.

Free access
in American Journal of Veterinary Research

Abstract

Objective

To evaluate the feasibility of using a subconjunctivally implanted micro-osmotic pump for continuous delivery of medication to the eyes of horses-during a 7-day period.

Animals

4 healthy adult horses.

Procedure

With horses restrained in a standing position, micro-osmotic pumps were implanted sub-conjunctivally in each eye for 7 days. The treatment eye received an atropine-loaded micro-osmotic pump (100 μl of 1.5% atropine), and the contralateral eye received a sterile saline-loaded pump (100 μl of 0.9% NaCl) as a control treatment. Pupil size was measured at 12-hour intervals until values returned to baseline.

Results

The micro-osmotic pumps were tolerated and did not migrate or become dislodged. During the 7-day treatment period, pupils were significantly larger in the eyes implanted with atropine-loaded pumps, compared with saline-implanted control eyes.

Conclusions and Clinical Relevance

Micro-osmotic pumps were implanted and removed easily from standing horses and were not associated with complications during the 7-day treatment period. Therefore, subconjunctivally implanted micro-osmotic pumps can potentially be used when treating ophthalmic disease in horses. (Am J Vet Res 1999;60:1102-1105)

Free access
in American Journal of Veterinary Research