Objective—To determine changes in serum feline
trypsin-like immunoreactivity (fTLI) in response to
administration of ceruletide to healthy cats.
Animals—11 healthy cats.
Procedures—Serum fTLI was determined, using a
radioimmunoassay, before and 10, 20, 30, 40, and 50
minutes after IM administration of ceruletide (0.3
mg/kg [0.14 mg/lb]).
Results—Mean ± SD baseline serum fTLI was 23.1 ±
4.1 mg/L. There was a statistically significant, but clinically
unimportant, increase in serum fTLI 10 and 30
minutes after ceruletide administration.
Conclusions and Clinical Relevance—In healthy
cats, administration of ceruletide induced a statistically
significant, but clinically unimportant, increase in
serum fTLI. Whether responses in cats with exocrine
pancreatic disorders would be different is unknown,
but results suggest that a ceruletide stimulation test
would likely not be useful for differentiating between
healthy cats and cats with subclinical chronic exocrine
pancreatic disorders. (Am J Vet Res 2000;61:925–927)