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- Author or Editor: Ilona Rodan x
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Abstract
Objective—To determine intraocular pressure (IOP) in cats ≥ 7 years of age undergoing a routine comprehensive geriatric health examination.
Design—Prospective study.
Animals—538 cats (1,068 eyes).
Procedure—IOP was measured by applanation tonometry following instillation of 0.5% proparacaine.
Results—Mean ± SD IOP for all eyes was 12.3 ± 4.0 mm Hg (range, 4 to 31 mm Hg). Mean age was 12.3 ± 2.9 years. Intraocular pressure did not vary significantly cross-sectionally with age. However, in 78 cats, IOP was measured more than once, and follow-up measurements were significantly less than initial measurements (mean time between measurements, 9.4 ± 3.0 months). The most useful tonometric criteria for identifying ocular abnormalities on the basis of IOP was an IOP ≥ 25 mm Hg (mean + 3 SD) or a difference in IOP between eyes ≥ 12 mm Hg. Eight cats met these criteria, and 5 of these cats had ophthalmic abnormalities. Low IOP was a nonspecific indicator of the presence of ocular abnormalities, as 111 cats had an IOP ≤ 8 mm Hg, but only 2 had uveitis.
Conclusions and Clinical Relevance—Results suggest that IOP measurements can be a useful addition to a comprehensive geriatric health examination in cats ≥ 7 years of age, especially when combined with an ophthalmic examination. Cats without ocular abnormalities that have IOP ≥ 25 mm Hg or a ≥ 12 mm Hg difference in IOP between eyes should have tonometry repeated or be referred to an ophthalmologist for further evaluation before beginning antiglaucoma treatment. (J Am Vet Med Assoc 2001;219: 1406–1410)
Abstract
Objective—To determine whether once daily administration of methimazole was as effective and safe as twice daily administration in cats with hyperthyroidism.
Design—Randomized, nonblinded, clinical trial.
Animals—40 cats with newly diagnosed hyperthyroidism.
Procedure—Cats were randomly assigned to receive 5 mg of methimazole, PO, once daily (n = 25) or 2.5 mg of methimazole, PO, twice daily (15). A complete physical examination, including measurement of body weight; CBC; serum biochemical analyses, including measurement of serum thyroxine concentration; and urinalysis were performed, and blood pressure was measured before and 2 and 4 weeks after initiation of treatment.
Results—Serum thyroxine concentration was significantly higher in cats given methimazole once daily, compared with cats given methimazole twice daily, 2 weeks (3.7 vs 2.0 μg/dL) and 4 weeks (3.2 vs 1.7 μg/dL) after initiation of treatment. In addition, the proportion of cats that were euthyroid after 2 weeks of treatment was lower for cats receiving methimazole once daily (54%) than for cats receiving methimazole twice daily (87%). Percentages of cats with adverse effects (primarily gastrointestinal tract upset and facial pruritus) were not significantly different between groups.
Conclusions and Clinical Relevance—Results suggest that once daily administration of methimazole was not as effective as twice daily administration in cats with hyperthyroidism and cannot be recommended for routine use. (J Am Vet Med Assoc 2003; 222:954–958)
