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Abstract

Objective

To develop a surgical preparation to study the nutrient concentration difference across the portal vein-drained viscera of preruminant calves over a 2-week period.

Animals

9 healthy preruminant male Holstein calves.

Procedure

A bilateral subcostal approach was used to reach the portal area to provide access for proper placement of an ultrasonic transit time flow probe around the portal vein. The umbilical vein was used as an entry point for the portal vein catheter. The femoral artery was also catheterized. Calves were observed daily, and food intake was recorded. Body weight was recorded weekly. The calves were euthanatized, and necropsy was performed 2 weeks after surgery.

Results

Of the 9 calves, 7 recovered without surgical complications. Within 24 hours of surgery, 1 calf developed an intestinal hernia at the flank incision that was surgically repaired without further complications. One calf was euthanatized a week after surgery because it developed septicemia secondary to catheter-related infection.

Conclusion

The bilateral subcostal approach provided access to the portal area, and the umbilical vein was useful as an entry point. Application of an ultrasonic flow probe provided consistent measurements of blood flow over a 2-week period.

Clinical Relevance

These results may have implications for development of treatment to promote gastrointestinal tract healing in calves with diarrhea. (Am J Vet Res 1998;59:1323-1328)

Free access
in American Journal of Veterinary Research

Abstract

Objective—To determine tracheal mucociliary clearance rate (TMCCR) by use of a standard protocol in healthy anesthetized cats and to determine the effect of theophylline on TMCCR in healthy anesthetized cats.

Animals—6 healthy cats.

Procedure—Cats were anesthetized with propofol, and a droplet of the radiopharmaceutical technetium Tc 99m macroaggregated albumin was placed endoscopically at the carina. Dynamic acquisition scintigraphic imaging was performed, using the larynx as the end point. The TMCCR was determined by measuring the distance the droplet traveled by frame rate. Each cat was imaged 6 times as follows: 3 times following placebo administration and 3 times following the administration of sustained release theophylline (25 mg/kg, PO). Serum theophylline concentrations were assessed during imaging to ensure therapeutic concentrations.

Results—The TMCCR in healthy adult cats anesthetized with propofol was 22.2 ± 2.8 mm/min. Tracheal mucociliary clearance rate in cats receiving theophylline was 21.8 ± 3.5 mm/min. Theophylline administration did not significantly alter TMCCR.

Conclusion and Clinical Relevance—Theophylline has been shown to increase TMCCR in humans and dogs. In our study, we determined TMCCR in healthy anesthetized cats and found that it was not accelerated by the administration of theophylline. (Am J Vet Res 2002;63:1320–1322)

Full access
in American Journal of Veterinary Research