A Holstein heifer calf was born during an uneventful parturition in the evening and received 4 quarts of maternal colostrum within 2 hours after birth. The following morning, the calf was bloated and repeated attempts by both the owners and the referring veterinarian to reduce the abdominal distension by orogastric intubation were unsuccessful. The referring veterinarian was able to extract a small amount of feces from the rectum. On the farm, the calf received treatment with flunixin meglumine, penicillin, and electrolytes.
Clinical and Gross Findings
The 24-hour-old calf was evaluated at the University of Wisconsin-Madison Veterinary Medical Teaching Hospital
Objective—To evaluate progesterone and estrogen
receptor expression in meningiomas of the CNS in
dogs and cats.
Animals—8 dogs (1 of which was treated with gestrinone)
and 5 cats with intracranial meningiomas and 2
dogs with spinal cord meningiomas; tissue samples
were also obtained from 1 clinically normal dog and 1
clinically normal cat.
Procedure—Meningioma tissue was obtained during
surgery or at necropsy; samples were processed for
histologic classification and immunohistochemical
evaluation of the proportion of tumor cells with progesterone
and estrogen receptors. Correlation among
receptor expression, tumor grade, and histologic subtypes
Results—Several histologic subtypes of intracranial
meningiomas were detected among tissue samples.
In the cats, all intracranial meningiomas were benign.
Progesterone receptor immunoreactivity was detected
in 14 of 15 meningiomas. Progesterone receptor
expression was identified in > 80% of cells in 8
intracranial meningiomas (4 dogs and 4 cats) and 2
spinal cord meningiomas. In samples of malignant
transitional and granular cell meningiomas in dogs,
progesterone receptors were detected in 32 and
4.8% of cells respectively. In 1 cat, 38% of tumor
cells had progesterone receptors. In a dog treated
with gestrinone, no progesterone receptors were
detected in the intracranial meningioma. Estrogen
receptors were only detected in the tumor of 1 dog.
Conclusions and Clinical Relevance—Results indicate
a high proportion of progesterone receptors in
cells of meningiomas of the CNS in dogs and cats.
Antiprogesterone treatment may have a role in the
treatment of unresectable or recurrent meningiomas
in dogs and cats. (Am J Vet Res 2003;64:1310–1318)
A 4-year-old 11.4-kg (25.1-lb) sexually intact female Shetland Sheepdog was referred to the University of Wisconsin Veterinary Care neurology service because of sudden-onset ataxia of 12 hours' duration. At the initial evaluation, the dog's abnormalities were limited to the neurologic system.
Etiologic diagnosis—The primary differential diagnoses for this dog included meningoencephalitis (infectious or inflammatory), neoplasia (meningioma, lymphoma, glioma, ependymoma, or choroid plexus neoplasm), acute vascular event, or cyst. The diagnostic plan included a CBC, serum biochemical analysis, urinalysis, thoracic radiography, and abdominal ultrasonography (to evaluate for evidence of compressive, inflammatory, or infectious disease), brain MRI (with and without gadolinium
A 2-year-old Pionus parrot was evaluated for cachexia and partial anorexia of 3 weeks' duration. The bird was 1 of 2 privately owned birds and was on a predominantly sunflower seed–based diet with some pellets offered. The bird's history was unremarkable except for an incident approximately 1 year earlier when it flew into a river behind the owners' house. The bird was rescued and given oxygen at the local veterinary clinic.
Physical examination revealed signs of depression, severe emaciation, and tachypnea, with effort, worsened by restraint; however, auscultation did not reveal abnormalities. Palpation of the coelom revealed