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  • Author or Editor: Hisashi Shibuya x
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To assess variations in age, breed, and clinical signs in rabbits with neoplastic or nonneoplastic uterine lesions and to investigate potential relationships between endometrial adenocarcinoma and age at ovariohysterectomy or breed in rabbits.


1,928 rabbits that underwent ovariohysterectomy for treatment or prevention of possible uterine disease.


With an online questionnaire distributed to 441 veterinary hospital members of the Japanese Society of Exotic Pet Medicine, data were retrospectively collected regarding age, breed, and findings on physical and histologic examinations for pet rabbits that underwent ovariohysterectomy between January 1, 2009, and April 30, 2018. Rabbits were grouped by reported age, breed, clinical signs, and uterine lesions, and results were assessed across groups. Logistic regression analysis was used to identify potential relationships between endometrial adenocarcinoma and breed or age at ovariohysterectomy in rabbits.


The questionnaire response rate was 9.8% (43/441), with data reported for 1,928 rabbits (mixed breed, 600 [31.1%]; Netherland Dwarf, 520 [27.0%]; Holland Lop, 286 [14.8%]; or various other breeds, 522 [27.1%]). The most commonly reported neoplastic and nonneoplastic lesions were endometrial adenocarcinoma (1,035/1,928 [53.7%]) and endometrial hyperplasia (842 [43.7%]), respectively, and the most commonly reported clinical sign was hematuria or serosanguineous vaginal discharge (1,020/1,928 [52.9%]). As age at ovariohysterectomy increased, so did the odds (OR, 1.826; 95% CI, 1.640 to 2.033) of uterine adenocarcinoma.


Results supported ovariohysterectomy in rabbits before 2 years of age as a key preventative measure to mitigate uterine disease, particularly endometrial adenocarcinoma.

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in Journal of the American Veterinary Medical Association


A closely inbred line of Chow Chows affected with congenital cataracts was studied. Sixteen dogs were examined including 1 adult male, 2 adult females, and 13 pups. Twelve of the pups were from 6 different litters, out of 6 different bitches, all sired by 1 adult male. The exact relationship of the thirteenth pup was undetermined. Clinical evaluation included slit-lamp biomicroscopy, biomicroscopic photography, and indirect ophthalmoscopy. Clinical appearance of the cataracts was variable, ranging from incipient nuclear or capsular lesions to advanced cortical opacity. The lens nucleus was most consistently affected, with variable involvement of the lens cortex. Concurrent ocular anomalies of some eyes included wandering nystagmus, entropion, microphthalmia, persistent pupillary membrane remnants, and multifocal retinal folds. A correlation was not apparent between the character or severity of the cataracts and the fnding of the other anomalies. Histologic examination of 12 lenses revealed posterior displacement of the lens nucleus, retained lens epithelial cell nuclei in the nuclear and cortical lens, anterior capsular irregularity and duplication, anterior lens epithelial duplication, and posterior subcapsular migration of epithelium. The high incidence of cataract in this family of Chow Chows suggested an inherited defect, although the inheritance pattern was undetermined.

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in Journal of the American Veterinary Medical Association