CASE DESCRIPTION A 3-year-old and a 7-year-old spayed female rabbit (Oryctolagus cuniculus) were evaluated because of digestive stasis associated with renal asymmetry.
CLINICAL FINDINGS Neoplasia of the right kidney was diagnosed via cytologic analysis in the 3-year-old rabbit. Ureterolithiasis of the left kidney was diagnosed via abdominal ultrasonography in the 7-year-old rabbit. To evaluate whether unilateral nephrectomy was indicated, evaluation of glomerular filtration rate by dynamic CT (CT-GFR) was performed on both rabbits. On the basis of the functional and morphological CT-GFR results, radical nephrectomy was recommended for the rabbit with renal neoplasia whereas a more conservative approach was recommended for the other rabbit.
TREATMENT AND OUTCOME The rabbit with renal neoplasia underwent radical nephrectomy without complication. The rabbit with ureterolithiasis underwent ureteral stent placement, and the renal pelvic dilatation resolved. Both rabbits maintained unremarkable serum urea and creatinine concentrations after surgery.
CLINICAL RELEVANCE GFR is a highly useful and reliable variable for the evaluation of renal function but is difficult to assess with routine clinical laboratory tests. The CT-GFR technique described here was quickly performed, was technically suitable for rabbits, and provided clinically relevant information. Studies are required to establish reference values for CT-GFR in rabbits.
OBJECTIVE To determine the prognostic relevance of BUN concentration in client-owned rabbits evaluated at a veterinary referral center.
ANIMALS 246 healthy or clinically ill client-owned rabbits with BUN concentrations measured at a veterinary referral center.
PROCEDURES In a retrospective cohort study design, medical records of rabbits were retrieved, and data were collected on BUN concentration (exposure variable of interest) and other variables, including outcome (survival status at 15 days after BUN concentration measurement). Univariate, multivariate, and subgroup analyses were performed to identify variables associated with outcome.
RESULTS BUN concentrations ranged from 6.5 to 251.1 mg/dL (median, 18.7 mg/dL). Univariate analysis revealed that the risk of nonsurvival over the 15-day period for rabbits with a high BUN concentration (≥ 23.3 mg/dL) was 33% higher (relative risk, 1.33; 95% confidence interval [CI], 1.06 to 1.69) than that for rabbits with unremarkable BUN values. Subgroup analysis revealed that for rabbits with anorexia, a high (vs unremarkable) BUN concentration was associated with an increased risk of nonsurvival (relative risk, 1.69; 95% CI, 1.05 to 2.71). In the final multivariate model that controlled for age, sex, and appetite (anorexia vs no anorexia), the odds of nonsurvival for rabbits with BUN values > 24.74 mg/dL were 3 times that for rabbits with BUN values < 14.00 mg/dL (OR, 2.92; 95% CI, 1.29 to 6.58).
CONCLUSIONS AND CLINICAL RELEVANCE Results indicated that a high BUN concentration increased the risk of nonsurvival over a 15-day period for client-owned rabbits, particularly those with anorexia. Blood urea nitrogen concentration should be used together with other clinical indicators to provide prognostic information for rabbits receiving veterinary care.