Objective—To compare antibody responses to
intranasal and SC Bordetella bronchiseptica vaccines
in seropositive dogs.
Design—Randomized controlled study.
Animals—40 young adult Beagles vaccinated against
Procedure—Dogs were randomly assigned to 1 of 4
groups (intranasal vaccine, SC vaccine, intranasal and
SC vaccines, no vaccine) and vaccinated on day 0.
Serum and salivary B bronchiseptica-reactive antibody
responses were measured on days 0 through 7,
10, 14, 21, and 28.
Results—Dogs that were vaccinated with the SC vaccine,
alone or in combination with the intranasal vaccine,
had a significant increase in serum concentration
of B bronchiseptica-reactive IgG beginning on day 5
and persisting through day 28. Dogs that were vaccinated
with the intranasal vaccine alone had a significant
increase in serum concentration of B bronchiseptica-
reactive IgG beginning on day 10 and persisting
through day 28, but serum IgG concentration in these
dogs was significantly less than concentration in dogs
that received the SC vaccine. Neither vaccine had a
demonstrable effect on salivary concentrations of B
bronchiseptica-reactive IgA or IgG. On day 10, all vaccinated
groups had significantly higher serum IgA concentrations
than did unvaccinated control dogs.
Conclusions and Clinical Relevance—Results suggest
that the SC B bronchiseptica vaccine may be
used to stimulate antibody responses in seropositive
dogs. There was no apparent benefit to administering
these vaccines simultaneously. Intranasal vaccines
may not be effective for booster vaccination of dogs
previously exposed to or immunized against B bronchiseptica.
Dogs should be vaccinated at least 5 days
prior to exposure to B bronchiseptica. (J Am Vet Med