Objective—To investigate effects of IV administered
carprofen on indices of renal function and results of
serum biochemical and hematologic analyses in dogs
anesthetized with acepromazine-thiopentone-isoflurane
that had low blood pressure during anesthesia.
Animals—6 healthy Beagles.
Procedure—A randomized crossover study was conducted,
using the following treatments: saline (0.9%
NaCl solution)-saline, saline-carprofen, and carprofensaline.
Saline (0.08 ml/kg) and carprofen (4 mg/kg) were
administered IV. The first treatment was administered
30 minutes before induction of anesthesia and immediately
before administration of acepromazine (0.1
mg/kg, IM). Anesthesia was induced with thiopentone
(25 mg/ml, IV) and maintained with inspired isoflurane
(2% in oxygen). The second treatment was administered
30 minutes after onset of inhalation anesthesia.
Blood gases, circulation, and ventilation were monitored.
Renal function was assessed by glomerular filtration
rate (GFR), using scintigraphy, serum biochemical
analyses, and urinalysis. Hematologic analysis was
performed. Statistical analysis was conducted, using
ANOVA or Friedman ANOVA.
Results—Values did not differ significantly among the
3 treatments. For all treatments, sedation and anesthesia
caused changes in results of serum biochemical
and hematologic analyses, a decrease in mean
arterial blood pressure to 65 mm Hg, an increase of
115 pmol/L in angiotensin II concentration, and an
increase of 100 seconds in time required to reach
maximum activity counts during scintigraphy.
Conclusions and Clinical Relevance—Carprofen
administered IV before or during anesthesia did not
cause detectable significant adverse effects on renal
function or results of serum biochemical and hematologic
analyses in healthy Beagles with low blood pressure
during anesthesia. (Am J Vet Res 2002;63:
Objective—To investigate effects of carprofen on indices of renal function and results of serum bio-chemical analyses and effects on cardiovascular variables during medetomidine-propofol-isoflurane anesthesia in dogs.
Animals—8 healthy male Beagles.
Procedures—A randomized crossover study was conducted with treatments including saline (0.9% NaCl) solution (0.08 mL/kg) and carprofen (4 mg/kg) administered IV. Saline solution or carprofen was administered 30 minutes before induction of anesthesia and immediately before administration of medetomidine (20 μg/kg, IM). Anesthesia was induced with propofol and maintained with inspired isoflurane in oxygen. Blood gas concentrations and ventilation were measured. Cardiovascular variables were continuously monitored via pulse contour cardiac output (CO) measurement. Renal function was assessed via glomerular filtration rate (GFR), renal blood flow (RBF), scintigraphy, serum biochemical analyses, urinalysis, and continuous CO measurements. Hematologic analysis was performed.
Results—Values did not differ significantly between the carprofen and saline solution groups. For both treatments, sedation and anesthesia caused changes in results of serum biochemical and hematologic analyses; a transient, significant increase in urine alkaline phosphatase activity; and blood flow diversion to the kidneys. The GFR increased significantly in both groups despite decreased CO, mean arterial pressure, and absolute RBF variables during anesthesia.
Conclusions and Clinical Relevance—Carprofen administered IV before anesthesia did not cause detectable, significant adverse effects on renal function during medetomidine-propofol-isoflurane anesthesia in healthy Beagles.
Objective—To assess physiologic responses and plasma endothelin (ET)-1 concentrations associated with abrupt cessation of nitric oxide (NO) inhalation in isoflurane-anesthetized horses.
Animals—6 healthy adult Standardbreds.
Procedures—Horses were anesthetized with isoflurane in oxygen and placed in dorsal recumbency. Nitric oxide was pulsed into the respiratory tract for 2.5 hours, and then administration was abruptly discontinued. Just prior to commencement and at cessation of NO administration, and at intervals during a 30-minute period following cessation of NO inhalation, several variables including PaO2, mean pulmonary artery pressure, venous admixture or pulmonary shunt fraction (Qs/Qt), and plasma ET-1 concentration were recorded or calculated.
Results—After cessation of NO inhalation, PaO2 decreased slowly but significantly (172.7 ± 29.8 mm Hg to 84.6 ± 10.9 mm Hg) and Qs/Qt increased slowly but significantly (25 ± 2% to 40 ± 3%) over a 30-minute period. Mean pulmonary artery pressure increased slightly (14.0 ± 1.3 mm Hg to 16.8 ± 1 mm Hg) over the same time period. No change in serum ET-1 concentration was detected, and other variables did not change or underwent minor changes.
Conclusions and Clinical Relevance—The improvement in arterial oxygenation during pulsed inhalation of NO to healthy isoflurane-anesthetized horses decreased only gradually during a 30-minute period following cessation of NO inhalation, and serum ET-1 concentration was not affected. Because a rapid rebound response did not develop, inhalation of NO might be clinically useful in the treatment of hypoxemia in healthy isoflurane-anesthetized horses.