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Objective

To measure serum α1-antitrypsin (α1AT) concentration in dogs with histologically confirmed panniculitis to determine whether serum deficiency could cause or exacerbate panniculitis in dogs.

Design

Cross-sectional, descriptive study.

Animals

9 dogs (5 with multiple lesions and 4 with solitary lesions).

Procedure

Serum samples were obtained by means of cephalic or jugular venipuncture and frozen at −20 C until assayed. Serum α1AT concentration was measured by means of radial gel immunodiffusion.

Results

In all dogs, serum α1AT concentration was within the previously established reference range.

Clinical Implications

In the small number of dogs studied, panniculitis was not associated with serum α1AT deficiency. (J Am Vet Med Assoc 1996;209:1582–1584)

Free access
in Journal of the American Veterinary Medical Association

SUMMARY

We performed a study to determine a reference range for serum α1-antitrypsin (α1 at) in dogs by specific immunoassay; to evaluate whether serum α1 at concentration varied with age, sex, or reproductive status in healthy dogs; and to investigate whether the serum α1 at concentration in hospitalized dogs differed from that of healthy, nonhospitalized dogs. Serum α1 at was quantitated by radial gel immunodiffusion for 60 healthy dogs and 311 hospitalized dogs. In healthy dogs, serum α1 at concentration was 2.33 ± 0.41 mg/ml (mean ± sd), yielding a reference range (mean ± 2 sd) of 1.51 to 3.15 mg/ml. A correlation was not found between serum α1 at concentration and age in healthy dogs. The serum α1 at concentration (mean ± sem mg/ml) was significantly higher in healthy, sexually intact females (2.64 ± 0.1) than in healthy, spayed females (2.22 ± 0.12; P < 0.004); healthy, sexually intact males (2.14 ± 0.1; P < 0.0006); and healthy, castrated males (2.25 ± 0.14; P < 0.02). Hospitalized, sexually intact females had a lower serum α1 at concentration (1.93 ± 0.07) than healthy, sexually intact females (2.64 ± 0.1; P < 0.0002). Likewise, the serum α1 at concentration in hospitalized, sexually intact males (1.92 ± 0.04) was less than in healthy, sexually intact males (2.14 ± 0.1; P < 0.04). A difference in α1 at concentration was not found between healthy and hospitalized, neutered dogs.

Free access
in American Journal of Veterinary Research