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  • Author or Editor: Francisco Gonzalez x
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Abstract

Objective—To determine the pharmacokinetics after SC administration of an experimental, long-acting parenteral formulation of doxycycline hyclate in a poloxamer-based matrix and after IV and IM administration of an aqueous formulation of doxycycline hyclate in goats.

Animals—30 clinically normal adult goats.

Procedures—Goats were allocated to 3 groups (10 goats/group). One group of goats received doxycycline hyclate (10 mg/kg) IM, a second group received the same dosage of doxycycline hyclate IV, and the third group received the long-acting parenteral formulation of doxycycline hyclate SC. Serum concentrations of doxycycline were determined before and at various intervals after administration.

Results—The long-acting parenteral formulation of doxycycline hyclate had the greatest bioavailability (545%); mean ± SD maximum serum concentration was 2.4 ± 0.95 μg/mL, peak time to maximum concentration was 19.23 ± 2.03 hours, and elimination half-life was 40.92 ± 4.25 hours.

Conclusions and Clinical Relevance—Results indicated that the long-acting parenteral formulation of doxycycline hyclate distributed quickly and widely throughout the body after a single dose administered SC, and there was a prolonged half-life. Bioavailability of the longacting parenteral formulation of doxycycline hyclate after SC administration was excellent, compared with bioavailability after IV and IM administration of an aqueous formulation of doxycycline hyclate. Although no local tissue irritation and adverse effects were detected, clinical assessment of drug-residues and toxicologic evaluations are warranted before this long-acting parenteral formulation of doxycycline hyclate can be considered for use in goats with bacterial infections.

Full access
in American Journal of Veterinary Research

Abstract

OBJECTIVE

Burnout is a syndrome of emotional distress common in health-care professions. The aim of this study was to assess the potential levels of burnout syndrome among veterinarians in Spain as well as different factors involved in its prevalence.

SAMPLE

282 Spanish veterinarians (57.4% women and 42.6% men).

PROCEDURES

All data were obtained through an online survey. The instrument utilized for this purpose was the Maslach Burnout Inventory Human Services Survey (adapted to a Spanish-speaking population), with analyses performed using statistical software. Moreover, a sociodemographic questionnaire was utilized.

RESULTS

Within the considered population, 23% suffered from burnout syndrome and the average scores were 29 points for emotional exhaustion, 14 points for depersonalization, and 35 points for personal accomplishment. A higher prevalence of burnout was associated with small animal clinicians (75.3%) and women (66.1%), in comparison to large animal clinicians (24.6%) and men (33.8%).

CLINICAL RELEVANCE

This study showed for the first time that burnout syndrome is a current and highly relevant risk for Spanish veterinarians. The results obtained could help to raise awareness of this reality and the factors involved in the development or exacerbation of this syndrome.

Full access
in Journal of the American Veterinary Medical Association