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  • Author or Editor: Frédérique Woehrlé x
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Objective—To study the hemodynamic effects of marbofloxacin (MBF) in isoflurane-anesthetized dogs.

Animals—6 healthy 8-month-old Beagles.

Procedure—Anesthesia was induced with sodium thiopental and maintained with isoflurane. Cardiovascular variables were monitored throughout anesthesia. Marbofloxacin was administered by an IV bolus at 2 mg/kg, followed 10 minutes later by an infusion at a rate of 40 mg/kg/h for 30 minutes (total dose, 20 mg/kg). Plasma MBF concentrations were measured by high-performance liquid chromatography.

Results—The mean peak concentration during MBF infusion was 34.2 ± 6.4 µg/mL. The IV administration of the MBF bolus did not alter any cardiovascular variable in isoflurane-anesthetized dogs. Significant changes were found during infusion when a cumulative dose of 12 mg/kg had been given. The maximal decreases observed at the end of the infusion were 16% in heart rate, 26% in systolic left ventricular pressure, 33% in systolic aortic pressure, 38% in diastolic aortic pressure, 29% in cardiac output, and 12% in QT interval. All dogs recovered rapidly from anesthesia at the end of the experiment.

Conclusions and Clinical Relevance—MBF may safely be used at 2 mg/kg IV in isoflurane-anesthetized dogs, and significant adverse cardiovascular effects are found only when 6 to 8 times the recommended dose is given. (Am J Vet Res 2005;66:2090–2094)

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in American Journal of Veterinary Research


Objective—To compare the efficacy of adrafinil, propentofylline, and nicergoline for enhancing behavior of aged dogs.

Animals—36 Beagles between 9 and 16 years old.

Procedure—Dogs were randomly assigned to receive adrafinil (20 mg/kg of body weight, PO, q 24 h; n = 12), propentofylline (5 mg/kg, PO, q 12 h; 12), or nicergoline (0.5 mg/kg, PO, q 24 h; 12) for 33 days. Baseline behaviors in an open field and in kennels (home cage) were recorded before treatment. After treatment, behaviors in the open field were recorded 2 hours after drug administration on days 2, 15, and 28, and 10 hours after administration on days 7, 20, and 33. Behaviors in the home cage were recorded 2 and 7 hours after drug administration on days 4, 17, and 30.

Results—Treatment with adrafinil resulted in a significant increase in locomotion in each of the open-field tests and an increase in locomotion in the home cage. This latter increase was smaller and more variable than that in the open field. Locomotion was not affected by treatment with propentofylline or nicergoline. In the open field, sniffing decreased over time in all 3 groups, but the largest decline was observed in the propentofylline group.

Conclusions and Clinical Relevance—Treatment with adrafinil may improve the quality of life of aged dogs by increasing exploratory behavior and alertness. (Am J Vet Res 2000;61:1410–1414)

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in American Journal of Veterinary Research