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  • Author or Editor: Emma L. Rowe x
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Abstract

Objective—To determine whether excision was an acceptable treatment for dermal melanomatosis in horses.

Design—Retrospective study.

Animals—11 horses with dermal melanomatosis involving the perineal, perianal, or perirectal region or ventral surface of the tail in which treatment consisted of tumor excision.

Procedure—Medical records were reviewed. Followup information was obtained from owners through telephone interviews.

Results—9 of the 11 horses were alive at the time of follow-up interviews. None of the horses had regrowth at the surgery site where the primary tumor was removed. There were no confirmed clinical signs of internal metastasis.

Conclusions and Clinical Relevance—Results suggest that excision of dermal melanomatosis in horses may be a reasonable treatment option. (J Am Vet Med Assoc 2004;225:94–96)

Restricted access
in Journal of the American Veterinary Medical Association

Abstract

Objective—To identify apoptosis in equine intestines and determine whether apoptosis is associated with gastrointestinal tract disease or a specific tissue layer of intestine.

Animals—38 horses that underwent surgery or were euthanatized for small or large intestine obstruction, strangulation, or distension and 9 control horses euthanatized for reasons other than gastrointestinal tract disease or systemic disease.

Procedure—Specimens were collected at surgery from intestine involved in the primary lesion and distant to the primary lesion site or at necropsy from several sites including the primary lesion site. Histologic tissue sections were stained with H&E, and apoptosis was detected by use of the terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling technique. The number of apoptotic cells per hpf was counted in the mucosa, circular muscle, longitudinal muscle, and serosa.

Results—Apoptotic nuclei were seen in all layers of intestine. An increased number of apoptotic cells was found in the circular muscle of the intestine from horses with simple obstruction, compared with strangulating obstruction or healthy intestine. Intestine distant from a primary strangulating lesion had higher numbers of apoptotic cells than did intestine distant from a simple obstructive lesion or intestine taken at the site of a strangulating or simple obstructive lesion.

Conclusions and Clinical Relevance—Intestine from horses with obstructing or strangulating lesions in the small intestine and large colon had high numbers of apoptotic cells possibly because of ischemic cell injury and subsequent inflammation. Whether substantial apoptosis affects intestinal function is not yet known. (Am J Vet Res 2003;64:982–988)

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in American Journal of Veterinary Research