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  • Author or Editor: E. M. Shobe x
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Effects of 1 hour of colonic volvulus and 3 hours of reperfusion on concentrations of thromboxane (txb 2) and prostacyclin (6-keto-PGF) in portal, pulmonary arterial, and jugular blood were determined by radioimmunoassay to assess the site of production and clearance of these eicosanoids from the circulation in 5 anesthetized ponies. Colonic volvulus had no significant effect on mean arterial pressure or txb 2 concentrations, but significantly (P < 0.05) increased 6-keto-PGF concentrations in all blood samples. Immediately after colonic reperfusion, all eicosanoid concentrations were significantly (P < 0.05) increased. Then, txb 2 returned to baseline values, whereas 6-keto-PGF concentrations remained significantly (P < 0.05) high for the remainder of the study. Eicosanoid concentrations were significantly (P < 0.05) greater in portal blood than in pulmonary arterial and jugular blood samples at all periods. This suggests that the splanchnic circulation is the primary site of eicosanoid production during and after colonic volvulus and the liver appears to provide most of the circulatory clearance of thromboxane and prostacyclin.

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in American Journal of Veterinary Research