Search Results

You are looking at 1 - 2 of 2 items for

  • Author or Editor: Craig M. Mallinckrodt x
  • Refine by Access: All Content x
Clear All Modify Search

Objective

To determine response rate and remission as well as survival times for dogs with multicentric lymphoma treated first with doxorubicin alone or in combination with asparaginase and then with cyclophosphamide, vincristine sulfate, and prednisone (CVP) and to identify prevalence of toxicoses associated with this protocol and factors associated with prognosis.

Design

Retrospective case series.

Animals

121 dogs.

Procedure

Variables evaluated for prognostic value were initial response rate to chemotherapy, age, breed, sex, body weight, histologic grade, clinical stage and substage, previous corticosteroid treatment, and serum calcium concentration.

Results

Median overall remission and survival times for all 121 dogs were 205 and 237 days, respectively. Response rate (complete or partial response) was 88%. Ten dogs were hospitalized because of toxicoses associated with doxorubicin, and 19 dogs were hospitalized because of toxicoses associated with CVP. Asparaginase favorably influenced the initial response rate, but did not significantly influence overall remission or survival times. Initial response rate to chemotherapy, body weight. clinical substage, and serum calcium concentration was found to have prognostic value.

Clinical Implications

For dogs with multicentric lymphoma, treatment with doxorubicin alone or in combination with asparaginase and then with CVP resulted in an acceptable response rate and low prevalence of toxicoses. (J Am Vet Med Assoc 1997;210:512–516)

Free access
in Journal of the American Veterinary Medical Association

Objective

To determine the effects of IV administration of fluids on PCV, serum total protein and blood glucose concentrations, and systolic arterial pressure in healthy anesthetized dogs undergoing elective surgical procedures.

Design

Prospective, randomized controlled trial.

Animals

70 clinically normal dogs.

Procedure

Dogs received IV administration of 0, 5, 10, or 15 ml/kg of body weight/h of a polyionic crystalloid solution or 5% dextrose in water. Blood samples were collected before and after administration of medication, prior to anesthetic induction, after anesthetic induction, at the end of the surgical procedure, and 2 hours after surgery to determine PCV and serum total protein and blood glucose concentrations. Blood pressure was measured before and after anesthetic induction and at the end of the surgery.

Results

There were not any significant differences in PCV, total protein concentration, or systolic arterial pressure among treatment groups. Hyperglycemia developed in dogs receiving 5% dextrose in water, but resolved 2 hours after discontinuing administration of fluids.

Clinical Implications

Intravenous administration of fluids may not be necessary to maintain normal blood pressure in young, healthy dogs undergoing elective surgery. (J Am Vet Med Assoc 1996;208:2013-2015)

Free access
in Journal of the American Veterinary Medical Association