Search Results

You are looking at 1 - 4 of 4 items for

  • Author or Editor: Craig A. Jones x
  • Refine by Access: All Content x
Clear All Modify Search


Objective—To determine whether bovine herpesvirus 1 (BHV1), bovine viral diarrhea (BVDV) virus 1 (BVDV1), or BVDV 2 (BVDV2) were shed after parenteral administration of a multivalent modified-live virus vaccine.

Design—Prospective study.

Animals—28 healthy beef calves and 4 healthy pregnant beef cows.

Procedure—A commercially available modified-live virus multivalent vaccine was administered to steers and heifers (n = 18) that were seronegative to BHV1, BVDV1, and BVDV2. Four seronegative pregnant control cows were held in contact with the vaccinated calves for 103 days. Unvaccinated calves (n = 10) were held as controls in a separate double-fenced pen. Seroconversion was monitored by determining serum neutralization titers after vaccination. Viral shedding and viremia were assessed via analysis of nasal swab specimens and blood by use of polymerase chain reaction (PCR) and reverse transcriptase-PCR assays and virus isolation.

Results—A transient BVDV1 viremia was detected in most vaccinated calves 3 to 10 days after vaccination. All vaccinated calves seroconverted to BVDV1 and BVDV2. Seventeen of 18 vaccinated calves seroconverted to BHV1. Viral shedding was not detected in the vaccinated calves. All control cattle remained seronegative to BHV1, BVDV1, and BVDV2 throughout the study.

Conclusions and Clinical Relevance—Shedding of BHV1, BVDV1, and BVDV2 after vaccination was either nonexistent or undetected and did not result in transmission of BHV1, BVDV1, or BVDV2 vaccine viruses to pregnant contact control cows. (J Am Vet Med Assoc 2003;222:1399–1403)

Full access
in Journal of the American Veterinary Medical Association
in American Journal of Veterinary Research


Objective—To determine whether administration of 2 doses of a multivalent, modified-live virus vaccine prior to breeding of heifers would provide protection against abortion and fetal infection following exposure of pregnant heifers to cattle persistently infected (PI) with bovine viral diarrhea virus (BVDV) and cattle with acute bovine herpesvirus 1 (BHV1) infection.

Design—Randomized controlled clinical trial.

Animals—33 crossbred beef heifers, 3 steers, 6 bulls, and 25 calves.

Procedures—20 of 22 vaccinated and 10 of 11 unvaccinated heifers became pregnant and were commingled with 3 steers PI with BVDV type 1a, 1b, or 2 for 56 days beginning 102 days after the second vaccination (administered 30 days after the first vaccination). Eighty days following removal of BVDV-PI steers, heifers were commingled with 3 bulls with acute BHV1 infection for 14 days.

Results—After BVDV exposure, 1 fetus (not evaluated) was aborted by a vaccinated heifer; BVDV was detected in 0 of 19 calves from vaccinated heifers and in all 4 fetuses (aborted after BHV1 exposure) and 6 calves from unvaccinated heifers. Bovine herpesvirus 1 was not detected in any fetus or calf and associated fetal membranes in either treatment group. Vaccinated heifers had longer gestation periods and calves with greater birth weights, weaning weights, average daily gains, and market value at weaning, compared with those for calves born to unvaccinated heifers.

Conclusions and Clinical Relevance—Prebreeding administration of a modified-live virus vaccine to heifers resulted in fewer abortions and BVDV-PI offspring and improved growth and increased market value of weaned calves.

Full access
in Journal of the American Veterinary Medical Association
Tending Animals in the Global Village—A Guide to International Veterinary Medicine . . . . Import Risk Analysis: Animals and Animal Products . . . . Exotic Pests & Disease: Biology and Economics for Biosecurity . . . . Borna Disease Virus and Its Role in Neurobehavioral Disease . . . . Foot and Mouth Disease: Facing the New Dilemmas . . . . Trends in Emerging Viral Infections of Swine . . . . Clinical Examination of Farm Animals . . . . Manual of Sheep Diseases (2nd edition) . . . . Mycotoxins: Risks in Plant, Animal, and Human Systems . . . . A Guide to Plant Poisoning of Animals in North America . . . . Diseases of Poultry (11th edition) . . . . Modern Concepts of Immunology in Veterinary Medicine—Poultry Immunology (Advances in Medical and Veterinary Immunology) . . . . Pathology of Pet and Aviary Birds . . . . Birds of Prey: Health and Disease (3rd edition) . . . . Hand-Rearing Wild and Domestic Mammals . . . . Handbook of Wildlife Chemical Immobilization (International Edition) . . . . Veterinary Anesthesia and Pain Management Secrets . . . . The Veterinary ICU Book . . . . Anatomy of the Dog: An Illustrated Text (4th Edition) . . . . The 5-Minute Veterinary Consult Clinical Companion: Small Animal Dermatology . . . . Abdominal Radiology for the Small Animal Practitioner (Made Easy Series) . . . . Two Dimensional and M-Mode Echocardiography for the Small Animal Practitioner (Made Easy Series) . . . . Small Animal Ophthalmology Secrets . . . . Ocular Tumors in Animals and Humans . . . . Feline Oncology: A Comprehensive Guide to Compassionate Care . . . . Veterinary Medicine and Practice 25 Years in the Future and the Economic Steps to Get There
Full access
in Journal of the American Veterinary Medical Association