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  • Author or Editor: Christine A. Rees x
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in Journal of the American Veterinary Medical Association


Objective—To determine the effects of cephalexin and enrofloxacin on results of 4 commercially available urine glucose tests in dogs.

Animals—6 healthy adult female dogs.

Procedure—In a crossover design, cephalexin (22 and 44 mg/kg [10 and 20 mg/lb], PO, q 8 h) or enrofloxacin (5 and 10 mg/kg [2.3 and 4.5 mg/lb], PO, q 12 h) was administered to dogs for 1 day. Urine samples were tested for glucose at 0, 6, and 24 hours after drug administration. In vitro, dextrose was added to pooled glucose-negative canine urine samples containing either no antimicrobial or known concentrations of either antimicrobial; urine samples were then tested for glucose.

Results—In vivo, false-positive results were obtained by use of a tablet test in the presence of both antimicrobials and by use of a strip test in the presence of cephalexin. In vitro, false-positive results were obtained with the tablet test at the highest urine concentration of cephalexin (2,400 μg/mL) and with a strip test at the highest concentration of enrofloxacin (600 μg/mL). Enrofloxacin in urine samples containing dextrose caused the urine glucose tests to underestimate urine glucose concentration.

Conclusions and Clinical Relevance—Cephalexin and enrofloxacin at dosages used in clinical practice may result in false-positive or false-negative urine glucose results, and care should be taken when using urine as a basis for identifying or monitoring diabetic animals. (J Am Vet Med Assoc 2004;224:1455–1458)

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in Journal of the American Veterinary Medical Association


Objective—To determine whether systemic immunologic hyperreactivity exists in horses with chronic laminitis, compared with responses for nonlaminitic horses.

Animals—7 nonlaminitic horses and 7 CL horses.

Procedure—In experiment 1, intradermal testing (IDT) was performed on 7 nonlaminitic and 7 CL horses to evaluate the response to a combination of 70 allergens at 15 and 30 minutes and 4 and 24 hours after injection. Three nonlaminitic and 3 CL horses used in experiment 1 were used in experiment 2 to determine whether histologic differences existed between the 2 groups. The H&E-stained tissue sections were evaluated on the basis of 3 criteria. For all analyses, 2-sample t-tests were used to determine significant differences between the groups.

Results—In experiment 1, CL horses had significantly higher total responses to IDT than nonlaminitic horses at the first 3 time periods. Also, CL horses had significantly fewer total scores of 0 than nonlaminitic horses at all time periods, except at 24 hours. In experiment 2, we did not detect significant differences between groups for any criterion.

Conclusions and Clinical Relevance—Results support the hypothesis that CL horses develop hyperreactivity to various antigenic stimuli, compared with responses for nonlaminitic horses. Therefore, the possibility that antigenic challenge may result in exacerbation of clinical signs of laminitis should be discussed with horse owners. Chronic laminitis should also be a consideration when a horse becomes lame following antigenic challenges. (Am J Vet Res 2003;64:279–283)

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in American Journal of Veterinary Research