Objective—To compare myocardial concentrations of
fatty acids in dogs with dilated cardiomyopathy (DCM)
with concentrations in control dogs.
Sample Population—Myocardial tissues from 7
dogs with DCM and 16 control dogs.
Procedure—Myocardial tissues were homogenized,
and total fatty acids were extracted and converted to
methyl esters. Myocardial concentrations of fatty
acids were analyzed by use of gas chromatography
and reported as corrected percentages.
Results—The amount of docosatetraenoic acid
(C22:4 n-6) was significantly higher in myocardial samples
from dogs with DCM (range, 0.223% to 0.774%;
median, 0.451%), compared with the amount in samples
obtained from control dogs (range, 0.166% to
0.621%; median, 0.280%). There were no significant
differences between DCM and control dogs for concentrations
of any other myocardial fatty acids.
Conclusions and Clinical Relevance—Although concentrations
of most myocardial fatty acids did not differ
significantly between dogs with DCM and control
dogs, the concentration of docosatetraenoic acid was
significantly higher in dogs with DCM. Additional
investigation in a larger population is warranted to
determine whether this is a primary or secondary
effect of the underlying disease and whether alterations
in fatty acids may be a target for intervention in
dogs with DCM. (Am J Vet Res 2005;66:1483–1486)
Objective—To compare plasma fatty acid concentrations and the relationships of fatty acids to arrhythmias in Boxers versus Doberman Pinschers.
Animals—38 Boxers and 13 Doberman Pinschers.
Procedures—Boxers and Doberman Pinschers evaluated via Holter recording and for which a blood sample was available were included. Echocardiograms were performed in 49 of 51 dogs. The number of ventricular premature complexes (VPCs)/24 h was counted and fatty acids analyzed. Plasma fatty acid concentrations and VPCs/24 h, as well as correlations between the 2 variables, were compared between the 2 breeds.
Results—Compared with the Doberman Pinschers, Boxers had significantly higher plasma concentrations of γ-linolenic acid but lower concentrations of arachidonic acid. Total n-6 fatty acids and total polyunsaturated fatty acid concentrations were higher in Doberman Pinschers. There were significant, but weak, positive correlations between VPCs and oleic acid, total n-3 fatty acids, and total n-9 fatty acids in Boxers but not in Doberman Pinschers.
Conclusions and Clinical Relevance—Data suggested that plasma fatty acid concentrations may differ between Boxers and Doberman Pinschers and that the relationship between fatty acid concentrations and VPCs may be different between these 2 breeds.
Objective—To determine duration of administration,
complications, and frequency of aortic thromboembolism
associated with administration of low molecular
weight heparin (dalteparin) in cats.
Animals—57 cats treated with dalteparin.
Procedure—Data were recorded from the medical
records of cats treated with dalteparin, and owners
were contacted by telephone for information regarding
ease of administration and possible adverse
Results—Dalteparin was easily administered by owners.
Median dose was 99 U/kg (45 U/lb) once or twice
daily. Bleeding complications were infrequent. Of 43
cats with cardiomyopathy that received owner-administered
dalteparin for a median follow-up time of 172
days, 8 cats developed documented or possible arterial
Conclusions and Clinical Relevance—Dalteparin
was easily administered by owners and was well tolerated
by cats. Whether dalteparin administration can
reduce the frequency or severity of arterial thromboembolism
is not yet known. (J Am Vet Med Assoc