Objective—To use pedigree analysis to evaluate the
feasibility of a major locus model for deafness in
Animals—605 purebred Dalmatians from 42 families.
Procedure—Hearing loss was evaluated through the
brainstem auditory-evoked response. Dogs were
classified into mutually exclusive categories: normal
hearing, unilaterally deaf, or bilaterally deaf.
Information was collected on sex, coat color, presence
or absence of a color patch at birth, and eye
color. Statistical analyses were performed by use of
regressive logistic models designed for complex segregation
analysis. Genetic correlations among eye
color, deafness, and color patch were estimated.
Results—Prevalence of hearing loss was 11% for
dogs classified as unilaterally deaf and 5% for dogs
that were bilaterally deaf. Complex segregation analysis
detected statistical evidence of a single allele with
an expected frequency of 0.21 that had an effect on
the prevalence of deafness. Results of analyses suggested
that this locus cannot completely explain the
inheritance and incidence of deafness in Dalmatians.
Genetic correlation estimates among deafness, eye
color, and color patch revealed strong interrelationships
among these characteristics.
Conclusions and Clinical Relevance—To reduce the
incidence of hearing loss in Dalmatians, unilaterally
deaf, blue-eyed dogs should not be considered as
potential parents. ( Am J Vet Res 2000;61:550–553)
Current guidelines for the use of systemic antimicrobials for the treatment of superficial bacterial folliculitis in dogs include the recommendation that the disease be treated for a minimum of 3 weeks and for at least 1 week beyond clinical resolution. With increasing antimicrobial resistance being noted for bacteria involved in this condition, as well as the increased use of evidence-based medicine, this dogma needs to be reevaluated.