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  • Author or Editor: Brian M. Aldridge x
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Historical, physical, and clinicopathologic findings in 25 septicemic calves were examined to further characterize the clinical features of naturally induced bovine neonatal septicemia. Owners often reported single organ disease, but physical examination revealed multiple organ disease in more than half the calves. A third of the calves were admitted as representative of a herd problem. Laboratory findings were variable, but commonly included changes in the differential WBC count and plasma fibrinogen concentration. Low serum immunoglobulin concentrations were found in approximately half the calves.

Escherichia coli was the most frequently isolated organism, but gram-positive infections were found in 10%, and polymicrobial infections in 28%, of the calves. Previous antimicrobial administration did not appear to affect culture yield. At necropsy, lesions were seen in multiple organs in most calves. The respiratory and gastrointestinal systems were most commonly affected. Few of the calves had umbilical infections. The survival rate was poor (< 12%).

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in Journal of the American Veterinary Medical Association


Objective—To determine the nucleotide sequence of the equine intestinal fatty acid binding protein (I-FABP) gene, its expression in various regions of the gastrointestinal tract, and the use of measuring I-FABP in horses with colic.

Animals—86 horses with colic.

Procedure—The mRNA sequence for the I-FABP gene was obtained by use of a rapid amplification of complementary DNA ends technique. Comparative I-FABP gene expression was quantitated by use of a real-time reverse transcription-polymerase chain reaction assay. Amounts of I-FABP in abdominal fluid and plasma were measured by use of an ELISA kit. Association between I-FABP concentrations and clinical variables was performed by nonparametric analysis, and associations of these variables with intestinal ischemia were determined by the Spearman correlation test.

Results—The nucleotide sequence had 87% identity with human I-FABP. The I-FABP gene was highly expressed in the small intestinal mucosa but had low expression in the colon. High concentrations of I-FABP in abdominal fluid correlated with an increase in protein concentrations in peritoneal fluid and nonsurvival, whereas plasma I-FABP concentrations correlated with the necessity for abdominal surgery. Clinical variables associated with intestinal ischemia included the color and protein content of abdominal fluid and serum creatine kinase activity.

Conclusions and Clinical Relevance— Determination of I-FABP concentrations in abdominal fluid and plasma may be useful for predicting survival and the need for abdominal surgical intervention in horses with colic. Furthermore, serum creatine kinase activity and color and protein concentrations of abdominal fluid may be useful in the diagnosis of intestinal ischemia. (Am J Vet Res 2005;66:223–232)

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in American Journal of Veterinary Research
in Journal of the American Veterinary Medical Association