Objective—To evaluate use of lufenuron for treating
cutaneous fungal infections in dogs and cats.
Animals—156 dogs and 201 cats with dermatophytosis
or superficial dermatomycoses.
Procedure—Medical records were reviewed for dogs
and cats that had been treated for dermatophytosis or
other fungal infections by administration of lufenuron
and 18 dogs and 42 cats that were not treated and
served as a control group.
Results—Dogs were treated once by oral administration
of lufenuron tablets at doses ranging from
54.2 to 68.3 mg/kg (24.6 to 31.0 mg/lb) of body
weight. Samples of skin, scrapings, and hair were
obtained daily from 14 dogs with dermatophytosis;
mean durations from time of treatment to time of
negative fungal culture results and resolution of
gross lesions were 14.5 and 20.75 days, respectively.
In all treated dogs, gross lesions resolved within
approximately 21 days. Cats were treated once by
oral administration of lufenuron suspension in doses
ranging from 51.2 to 266 mg/kg (23.3 to 120.9 mg/lb).
Samples were obtained daily from 23 cats; mean
durations from time of treatment to time of negative
fungal culture results and resolution of gross lesions
were 8.3 and 12 days, respectively. Time to resolution
of lesions in most untreated control animals was
approximately 90 days. Adverse effects of treatment
were not detected.
Conclusions and Clinical Relevance—Results of
this study suggest that lufenuron provides an effective,
convenient, and rapid method for treating fungal
infections in dogs and cats. (J Am Vet Med Assoc