Objective—To investigate effects of IV administered
carprofen on indices of renal function and results of
serum biochemical and hematologic analyses in dogs
anesthetized with acepromazine-thiopentone-isoflurane
that had low blood pressure during anesthesia.
Animals—6 healthy Beagles.
Procedure—A randomized crossover study was conducted,
using the following treatments: saline (0.9%
NaCl solution)-saline, saline-carprofen, and carprofensaline.
Saline (0.08 ml/kg) and carprofen (4 mg/kg) were
administered IV. The first treatment was administered
30 minutes before induction of anesthesia and immediately
before administration of acepromazine (0.1
mg/kg, IM). Anesthesia was induced with thiopentone
(25 mg/ml, IV) and maintained with inspired isoflurane
(2% in oxygen). The second treatment was administered
30 minutes after onset of inhalation anesthesia.
Blood gases, circulation, and ventilation were monitored.
Renal function was assessed by glomerular filtration
rate (GFR), using scintigraphy, serum biochemical
analyses, and urinalysis. Hematologic analysis was
performed. Statistical analysis was conducted, using
ANOVA or Friedman ANOVA.
Results—Values did not differ significantly among the
3 treatments. For all treatments, sedation and anesthesia
caused changes in results of serum biochemical
and hematologic analyses, a decrease in mean
arterial blood pressure to 65 mm Hg, an increase of
115 pmol/L in angiotensin II concentration, and an
increase of 100 seconds in time required to reach
maximum activity counts during scintigraphy.
Conclusions and Clinical Relevance—Carprofen
administered IV before or during anesthesia did not
cause detectable significant adverse effects on renal
function or results of serum biochemical and hematologic
analyses in healthy Beagles with low blood pressure
during anesthesia. (Am J Vet Res 2002;63: