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Abstract

Objective—To determine the effectiveness of preinduction hyperbaric oxygen treatment (HBOT) in ameliorating signs of experimentally induced endotoxemia in horses.

Animals—18 healthy adult horses.

Procedures—Horses were randomly assigned to 1 of 3 equal-sized treatment groups to receive normobaric ambient air and lipopolysaccharide (LPS), HBOT and LPS, or HBOT and physiologic saline (0.9% NaCl) solution. Horses were physically examined, and blood was obtained for a CBC and to determine concentration or activity of plasma tissue necrosis factor-α, blood lactate, and blood glucose before the horses were treated with HBOT and then intermittently for 6 hours after administration of LPS or physiologic saline solution.

Results—All LPS-treated horses developed signs and biochemical and hematologic changes consistent with endotoxemia. Treatment with HBOT significantly ameliorated the effect of LPS on clinical endotoxemia score but did not significantly improve other abnormalities associated with endotoxemia.

Conclusions and Clinical Relevance—The protective effect of HBOT was minimal, and results did not support its use as a treatment for horses prior to development of endotoxemia.

Full access
in American Journal of Veterinary Research

SUMMARY

Blood ionized calcium (Ca2+) and pH; plasma lactate concentrations; and total protein, total calcium (CaT), albumin, and phosphorus concentrations in serum were determined in 40 healthy horses before (T1), at the finish line (T2), and 10 minutes after the finish (T3) of the cross-country phase of a 3-day-event competition. Mean (± sem) Ca2+ concentrations decreased from 6.22 ± 0.04 mg/dl at T1 to 5.04 ± 0.07 mg/dl at T2 (P ≤ 0.05). This decrease was accompanied by a nonsignificant increase in CaT between T1 and T2. The mean (± sem) percent ionization of calcium decreased significantly (P ≤ 0.05), from 50.9 ± 2.75% at T1 to 40.3 ± 3.58% at T2. Significant increases in mean albumin, total protein, phosphorus, and lactate concentrations and a significant decrease in mean pH were observed at T2 (P ≤ 0.05). At T3, mean Ca2+ and percent ionization had increased, but remained significantly less than resting values. Mean CaT was significantly decreased at T3, compared with values at T1 and T2. Correlation of mean Ca2+ concentration with all other measured variables at each time was evaluated; correlation coefficients between mean Ca2+ and all other variables were low (r 2 ≤ 0.38), indicating low biological significance.

Free access
in American Journal of Veterinary Research