Objective—To assess the effects of repeated episodes of propofol-associated anesthesia on quality of recovery from anesthesia, clinical status, and erythrocyte physiology in cats.
Animals—37 cats undergoing short-duration anesthesia for radiotherapy.
Procedures—Twice daily on 5 consecutive days, 13 cats with squamous cell carcinoma of the nasal planum (group 1) underwent anesthesia: first via administration of propofol or a midazolam (0.2 mg/kg [0.09 mg/lb])-propofol combination and then via administration of ketamine and midazolam each day (latter data were not analyzed). During a 19-day period, 24 cats with vaccineassociated sarcoma (group 2) were anesthetized 12 times with propofol or a midazolam-propofol combination. Anesthesia was maintained with propofol in both groups. Hematologic analysis was performed before, during, and on completion of radiotherapy; changes in Hct and hemoglobin concentration between groups were compared.
Results—Mean duration of anesthesia was 8.1 minutes (range, 5 to 20 minutes); no adverse events were detected during recovery. Total dose of propofol administered did not differ between groups 1 (6.34 mg/kg [2.88 mg/lb]) and 2 (4.71 mg/kg [2.14 mg/lb]). Midazolam administration decreased the propofol dose by 26%. Overall decreases from baseline in Hct and hemoglobin concentration were not significantly different between the 2 groups, nor clinically important; however, compared with baseline, values in group 2 were significantly lower after 6 and 12 anesthetic episodes for both protocols. Heinz bodies were identified in low numbers in both groups during radiotherapy.
Conclusions and Clinical Relevance—Results indicated that repeated propofol-associated short-duration anesthesia does not lead to clinically relevant hematologic changes in cats undergoing short-duration radiotherapy.
Objective—To investigate subjective and computerized
methods of evaluation of color Doppler (CD) and
power Doppler (PD) ultrasonographic images
(obtained before and after administration of contrast
medium) for quantitative assessment of vascularity
and perfusion of various naturally occurring tumors in
Sample Population—34 tumors in 34 dogs.
Procedure—Tumors in dogs were examined via CD
and PD ultrasonography before and after IV injection
of a microbubble contrast agent (pre- and postcontrast
examinations, respectively). Images were digitized
for subjective assessment of vessel density and
vascular pattern and computer-aided assessment of
parameters of vascularity (fractional area [FA]) and
perfusion (color-weighted FA [CWFA] and mean color
Results—With both analysis methods, more vessels
were identified in precontrast PD ultrasonographic
images than in precontrast CD ultrasonographic
images. Moreover, compared with values for precontrast
PD ultrasonography, FA, CWFA, and mean color
level were higher for postcontrast PD ultrasonography.
In postcontrast images, there was a significant
association between vessel densities determined
through subjective and computerized assessments.
Although sample size was small, vascularity of squamous
cell carcinomas was significantly greater than
that of other tumor types. Ten of the 19 soft tissue
sarcomas had low vessel density with minor contrast
enhancement. With increasing gross tumor volume,
FA and CWFA decreased for all Doppler ultrasonographic
Conclusions and Clinical Relevance—Higher values
of the ultrasonographic parameters representing vascularity
and perfusion of tumors in dogs were determined
via PD ultrasonography after administration of
contrast medium than via PD or CD ultrasonography
without administration of contrast medium. (Am J Vet Res 2005;66:21–29)