Search Results

You are looking at 1 - 6 of 6 items for

  • Author or Editor: Babetta A. Breuhaus x
  • Refine by Access: All Content x
Clear All Modify Search

Abstract

Objective—To determine whether ingestion of fescue seed infected with the endophyte Neotyphodium coenophialum would alter thyroid function in adult horses.

Design—Original study.

Animals—4 adult mares that were not pregnant and 6 adult geldings.

Procedure—Thyrotropin releasing hormone stimulation tests were performed while horses received a standard diet and after infected seed (2.3 kg/d [5 lb/d]) had been fed for 1 and 2 months. Serum prolactin concentrations were measured to verify endophyte absorption.

Results—Serum prolactin concentrations indicated that at least 8 of 10 horses absorbed the endophyte. Baseline concentrations of thyroid stimulating hormone, total and free triiodothyronine, and total and free thyroxine and the change in hormone concentrations in response to administration of thyrotropin releasing hormone (1 mg, IV) were not altered by ingestion of endophyte-infected fescue seed.

Conclusions and Clinical Relevance—Results suggest that ingestion of fescue seed infected with the endophytic fungus N coenophialum for 2 months has little effect on thyroid function in adult horses that are not pregnant. (J Am Vet Med Assoc 2003;223:340–345)

Full access
in Journal of the American Veterinary Medical Association

Summary

Pharmacokinetic values after iv administration of amikacin sulfate were determined for clinically normal and hospitalized foals during the first week of life. The relations between drug disposition and sepsis score and serum creatinine concentration also were studied. In clinically normal foals, differences in sepsis score, serum creatinine concentration, and pharmacokinetic variables of amikacin were not found between foals 1 to 3 and 4 to 7 days old. In hospitalized foals, sepsis score, serum creatinine concentration, area under the curve, area under the moment curve, and mean residence time were greater, and total clearance was decreased, compared with values in clinically normal foals. Sepsis score and serum creatinine concentration were inversely correlated to amikacin clearance and appeared to be useful indicators of altered drug disposition.

Free access
in Journal of the American Veterinary Medical Association

Abstract

Objective—To identify clinical signs, underlying cardiac conditions, echocardiographic findings, and prognosis for horses with congestive heart failure.

Design—Retrospective study.

Animals—14 horses.

Procedure—Signalment; history; clinical signs; clinicopathologic, echocardiographic, and radiographic findings; treatment; and outcome were determined by reviewing medical records.

Results—All 14 horses were examined because of a heart murmur; tachycardia was identified in all 14. Twelve horses had echocardiographic evidence of enlargement of 1 or more chambers of the heart. Other common clinical findings included jugular distention or pulsation, crackles, cough, tachypnea, and ventral edema. Nine horses had signs consistent with heart failure for > 6 days. Underlying causes for heart failure included congenital defects, traumatic vascular rupture, pericarditis, pulmonary hypertension secondary to heaves, and valvular dysplasia. Seven horses were euthanatized after diagnosis of heart failure; 5 were discharged but were euthanatized or died of complications of heart disease within 1 year after discharge. The remaining 2 horses were discharged but lost to follow-up.

Conclusions and Clinical Relevance—Results suggest that congestive heart failure is rare in horses. A loud heart murmur accompanied by either jugular distention or pulsation, tachycardia, respiratory abnormalities (crackles, cough, tachypnea), and ventral edema were the most common clinical signs. Echocardiography was useful in determining the underlying cause in affected horses. The long-term prognosis for horses with congestive heart failure was grave. (J Am Vet Med Assoc 2002;220:1512–1515)

Full access
in Journal of the American Veterinary Medical Association

Abstract

Objective

To determine pharmacokinetics of ibuprofen in healthy foals and to determine clinical effects after oral administration for 6 days.

Animals

7 healthy 5- to 10-week-old foals.

Procedure

Serum concentrations of ibuprofen were measured after IV and oral (nasogastric tube) administration at dosages of 10 and 25 mg/kg of body weight. Foals were given ibuprofen (25 mg/kg, PO, q 8 h) as a paste for 6 days. Serum and urine were obtained before and after the 6-day period.

Results

Half-life of elimination (Kel t1/2) of IV-administered ibuprofen (ie, 10 and 25 mg/kg), was 79 and 108 minutes, maximal serum concentration (C max ) was 82 and 160 μg/ml, and clearance was 0.003 and 0.002 L/kg/min, respectively. At the higher dosage, clearance was significantly lower and C max was significantly higher. Ibuprofen given via nasogastric tube resulted in Kel t1/2 of 81 and 100 minutes and C max of 22 and 52 μg/ml for 10 and 25 mg/kg, respectively. The absorption half-life was 13 minutes, and bioavailability ranged from 71 to 100%. Foals remained healthy during oral administration of ibuprofen. Serum urea nitrogen, creatinine, and l-iditol dehydrogenase values increased significantly, and γ-glutamyltransferase (GGT) activity and osmolality decreased, but all measurements remained within reference ranges. Urine GGT activity doubled. Necropsy did not reveal gross or histologic renal lesions attributable to ibuprofen. Acute gastric ulcers were evident in 1 foal, although clinical signs of ulcers were not observed.

Conclusions and Clinical Relevance

Ibuprofen can be given safely to healthy foals at dosages ≤ 25 mg/kg every 8 hours for up to 6 days. (Am J Vet Res 1999;60:1066-1073)

Free access
in American Journal of Veterinary Research
in Journal of the American Veterinary Medical Association