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History

A 12-year-old 7.5-kg (16.5-lb) neutered male Boston Terrier was evaluated by the referring veterinarian because of acute left-sided facial swelling and mild mucopurulent nasal discharge. Prednisone and amoxicillin-clavulanic acid treatment resulted in minimal response. Three weeks later, left-sided nasal discharge and facial swelling persisted with rightward deviation of the nasal planum. Over the following several weeks, signs of pain on palpation of the left-sided facial swelling became apparent and progressively worsened; ipsilateral exophthalmos had also developed. The dog was then referred to the University of Missouri Veterinary Health Center for further evaluation.

Clinical and Cytologic Findings

Physical examination revealed

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in Journal of the American Veterinary Medical Association
History

A 12-year-old 24.86-kg (54-lb) spayed female mixed-breed dog was evaluated because of polyuria and polydipsia that had persisted over a 3-month period. At the initial evaluation, the dog was found to be hypercalcemic (serum total calcium concentration, 12.8 mg/dL [reference interval, 9.2 to 11.3 mg/dL]; serum ionized calcium concentration, 1.77 mmol/L [reference interval, 1.12 to 1.40 mmol/L]). Other pertinent biochemical abnormalities detected at the time of hypercalcemia diagnosis included low-normal serum phosphorus concentration (2.1 mg/dL; reference interval, 2 to 5 mg/dL), low-normal serum parathyroid hormone concentration (0.60 pmol/L; reference interval, 0.50 to 5.80 pmol/L), and unmeasurably high plasma parathyroid

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in Journal of the American Veterinary Medical Association
History

A 3-year-old spayed female ferret was evaluated at the Louisiana State University Veterinary Teaching Hospital and Clinics because of a 3-week history of weight loss, lethargy, decreased appetite, nonproductive hacking cough, and abnormal feces (described by the owner as softer than normal for this ferret).

Clinical and Gross Findings

On physical examination, the ferret was in poor body condition (body condition score, 2/5). It was bright, alert, and responsive but tachypneic (100 breaths/min). Findings of abdominal palpation were suggestive of a possible abdominal mass and splenomegaly. No cutaneous lesions were observed. Results of a CBC and serum biochemical analysis

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in Journal of the American Veterinary Medical Association

Abstract

OBJECTIVE To compare percentages of mast cells in lymph node (LN) aspirate samples from clinically normal dogs, dogs with allergic dermatologic disease (ADD), and dogs with cutaneous mast cell tumors (MCTs).

DESIGN Prospective cross-sectional study.

ANIMALS 20 healthy dogs (group 1), 20 dogs with ADD (group 2), and 20 dogs with an MCT on the head or limbs (group 3).

PROCEDURES LN aspirate samples were obtained from easily accessible LNs in group 1, affected skin regions in group 2, and the likely draining LN or LNs of the MCT in group 3; the percentage of mast cells was manually determined for each LN. For group 3, LNs were cytologically categorized with a modified version of a published metastasis categorization scheme.

RESULTS Median (range) percentage of mast cells in aspirate samples was 0% (0% to 0.1%) for group 1, 0.05% (0% to 0.55%) for group 2, and 0.4% (0% to 77.4%) for group 3. In group 3, 16 LNs (13 dogs) were palpably normal in size; 6 of these had evidence of possible or certain metastasis. Seven LNs (7 dogs) in group 3 were palpably enlarged, and 5 of these had evidence of certain metastasis.

CONCLUSIONS AND CLINICAL RELEVANCE This study provided evidence to support the use of a uniform cytologic grading system to further define nodal metastasis in dogs with MCTs as well as estimates of the percentage of mast cells in LN aspirate samples for healthy dogs and dogs with ADD. Palpably normal LNs in dogs with cutaneous MCT may contain metastasis.

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in Journal of the American Veterinary Medical Association