An 11-year-old spayed female Border Collie mix was referred for a 2-month history of abdominal discomfort, lethargy, and intermittent vomiting. Hematemesis and melena were also observed over the 24 hours prior to admission. Previous treatment included a bland diet, famotidine, doxycycline, prednisone, azathioprine, metoclopramide, and sucralfate. No clinical improvement was appreciated.
Abnormalities found on physical examination included mild lethargy, a palpable mass in the cranioventral portion of the abdomen, and slight enlargement of the submandibular lymph nodes. The CBC revealed an inflammatory leukogram, microcytic normochromic anemia, and thrombocytosis. Serum biochemical analysis revealed high alanine transaminase and alkaline phosphatase activities
A 2.5-year-old spayed female Jack Russell Terrier was referred for surgical attenuation of a single congenital extrahepatic portosystemic shunt that had been detected via abdominal ultrasonography. The dog had a history of intermittent vomiting, pacing, and destructive behavior with acute exacerbation immediately prior to initial evaluation by the referring veterinarian. Preprandial (180 μmol/L; reference range, 0 to 12 μmol/L) and postprandial (246 μmol/L; reference rage, 0 to 16 μmol/L) serum bile acids concentrations were high, and serum biochemical analysis revealed hypoproteinemia (5.3 g/dL; reference range, 5.4 to 7.6 g/dL) and hypocholesterolemia (77 mg/dL; reference range, 135 to 361 mg/dL).
Objective—To estimate the prevalence of canine parvovirus (CPV) strains among dogs with enteritis admitted to a referral hospital in the southwestern United States during an 11-month period and to compare diagnostic test results, disease severity, and patient outcome among CPV strains.
Design—Prospective observational study.
Animals—72 dogs with histories and clinical signs of parvoviral enteritis.
Procedures—For each dog, a fecal sample or rectal swab specimen was evaluated for CPV antigen via an ELISA. Subsequently, fecal samples (n = 42 dogs) and pharyngeal swab specimens (16) were obtained and tested for CPV antigen via an ELISA and CPV DNA via a PCR assay. For specimens with CPV-positive results via PCR assay, genetic sequencing was performed to identify the CPV strain.
Results—56 dogs tested positive for CPV via ELISA or PCR assay. For 42 fecal samples tested via both ELISA and PCR assay, 27 had positive results via both assays, whereas 6 had positive PCR assay results only. Ten pharyngeal swab specimens yielded positive PCR assay results. Genetic sequencing was performed on 34 fecal or pharyngeal swab specimens that had CPV-positive PCR assay results; 25 (73.5%) were identified as containing CPV type-2c, and 9 (26.5%) were identified as containing CPV type-2b. No association was found between CPV strain and disease severity or clinical outcome.
Conclusions and Clinical Relevance—CPV type-2b and CPV type-2c posed similar health risks for dogs; therefore, genetic sequencing of CPV does not appear necessary for clinical management of infected patients. The diagnostic tests used could detect CPV type-2c.