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Serum concentrations of cefotaxime and desacetylcefotaxime were measured in 1-week-old pony foals after iv administration of a single dose of cefotaxime.

The cefotaxime disposition data conformed to a two-compartment model with elimination half-life of 0.60 hour. The combined cefotaxime and desacetylcefotaxime data was best described by a four-compartment model. The apparent half-life describing the disappearance of desacetylcefotaxime was 1.69 hours.

Dosage of 40 mg/kg of body weight given iv every 4 to 6 hours for neonatal foals with gram-negative septicemia and every 2 hours for foals with meningitis is recommended for further study.

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in American Journal of Veterinary Research