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  • Author or Editor: Gary Koritz x
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in Journal of the American Veterinary Medical Association

Summary

Effective renal plasma flow (erpf) was evaluated, using continuous-infusion p-aminohippurate clearance (clpah) and single-injection plasma clearance of technetium-99m mercaptoacetyltriglycine (99mTc-MAG3; clmag3) methods. Simultaneous clearance determinations were made in 6 dogs: 2 determinations for each dog before, and 1 determination after renal failure was induced by administration of amphotericin B. Linear regression analysis was used to derive an equation to estimate erpf from clmag3 after the single iv injection. A Student’s t-test was used to compare pharmacokinetics between the dogs when they were healthy and when they were in renal failure. An F-test was used to determine the appropriate Student’s t-test. Results indicated that clmag3 correlated reasonably well (r = 0.83, P < 0.0001) with erpf obtained from the clpah value. The volume of distribution and elimination of 99mTc-MAG3 decreased during renal failure. Although there was minimal binding of 99mTc-MAG3 to erythrocytes, it was significantly (P = 0.0008) lower during renal failure. Protein binding was not significantly different during renal failure. All dogs had signs of nausea and emesis at variable times after injection of 99mTc-MAG3. Determination of clmag3 after a single injection provides an adequate means to rapidly assess erpf in dogs. The technique could easily be performed in dogs with renal disease, thus providing valuable information regarding progression of naturally acquired renal failure.

Free access
in American Journal of Veterinary Research

SUMMARY

Sodium salicylate was administered to cattle and goats iv and po according to a crossover design. Total urinary excretion of sa and its metabolites was measured for 3 days after dosing. Salicyluric acid (sua) was the only metabolite detected in urine of either species. Recovery of sodium salicylate and sua in goats amounted to 67.9 and 34.6% of the dose, respectively, after iv administration. After oral dosing, total recoveries were 30.2% (sodium salicylate) and 71.7%(sua) of dose. By comparison, cattle excreted significantly (P < 0.05) less sodium salicylate (54.0%) and more sua (49.9%) after iv dosing. The same pattern was observed after oral administration, wherein cattle excreted < 12% as sodium salicylate and more than 99% as sua. In both species, almost 90% of the drug excreted as sodium salicylate was found in urine within the first 12 hours after an iv dose and within 24 hours after oral dosing. The excretion of sua was somewhat slower in both species, especially after oral administration. The data suggested that there were only quantitative differences in the metabolism and elimination of sodium salicylate between the 2 species, with cattle excreting a higher proportion of the drug as the glycine conjugate sua.

Free access
in American Journal of Veterinary Research