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–3 The best characterized downstream effectors of mTOR are the protein S6 kinases and eukaryotic translation initiation factor 4E binding protein 1 (ie, 4e-BP1). An mTOR-dependent activation of p70S6K1 promotes an increase in protein synthesis. The mTOR

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in American Journal of Veterinary Research

with a worse prognosis. 7 One of the regulatory protein kinases located downstream in the AKT pathway, mTOR, has been suggested to be of key importance in regulating translation of proteins involved in cell cycle progression and cellular proliferation

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in American Journal of Veterinary Research

anticancer properties have been recognized. 2 The mTOR acts as the nutrient sensor of the cell and integrates signals to regulate cell growth and metabolism. Rapamycin inhibits mTOR, which blocks the pathways required for cell-cycle progression

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in American Journal of Veterinary Research