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treat cats with occult HCM. Rapamycin, also known as sirolimus, a macrolide and inhibitor of the mechanistic (previously called mammalian) target of rapamycin (mTOR), shows promise as a novel therapeutic for feline HCM. 5 – 10 mTOR is an atypical

Open access
in Journal of the American Veterinary Medical Association

–3 The best characterized downstream effectors of mTOR are the protein S6 kinases and eukaryotic translation initiation factor 4E binding protein 1 (ie, 4e-BP1). An mTOR-dependent activation of p70S6K1 promotes an increase in protein synthesis. The mTOR

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in American Journal of Veterinary Research

with a worse prognosis. 7 One of the regulatory protein kinases located downstream in the AKT pathway, mTOR, has been suggested to be of key importance in regulating translation of proteins involved in cell cycle progression and cellular proliferation

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in American Journal of Veterinary Research

in horses 15 ; therefore, skeletal muscle mass is ultimately determined by the balance between the rates of muscle protein synthesis and breakdown. 16 Muscle protein synthesis is regulated through the mTOR-mTORC1 signaling pathway. The upstream

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in American Journal of Veterinary Research

modulated by a series of intracellular signaling cascades that are associated with the mTOR pathway (formerly mammalian target of rapamycin pathway). 10,11 The mTOR pathway regulates translation initiation and has been the subject of recent reviews. 10

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in American Journal of Veterinary Research

effects by modulating cytokine production, specifically by downregulating interferon-γ (IFN-γ) and upregulating IL-6 in cells derived from a monocyte cell line when exposed to histamine stimulation. The mammalian target of rapamycin (mTOR), a key regulator

Open access
in American Journal of Veterinary Research

intracellular signaling cascades that are associated with the mTOR pathway. The upstream signaling pathways and downstream effectors of the mTOR pathway and the effects of various anabolic stimuli on mTOR-dependent signaling have been the subject of several

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in American Journal of Veterinary Research

efficiency of ribosomes to translate mRNA into protein is modulated by a series of intracellular signaling cascades that are associated with the mTOR pathway. The mTOR pathway regulates translation initiation and has been the subject of recent reviews. 6

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in American Journal of Veterinary Research

anticancer properties have been recognized. 2 The mTOR acts as the nutrient sensor of the cell and integrates signals to regulate cell growth and metabolism. Rapamycin inhibits mTOR, which blocks the pathways required for cell-cycle progression

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in American Journal of Veterinary Research

breakdown have been reviewed in other reports. 18,19 Protein synthesis is regulated through the mTOR (formally mammalian target of rapamycin) signaling pathway. 19 The factors Akt, 4E-BP1, and rpS6 in horses have been evaluated in another study 20

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in American Journal of Veterinary Research